ENSG00000005007


Homo sapiens

Features
Gene ID: ENSG00000005007
  
Biological name :UPF1
  
Synonyms : Q92900 / UPF1 / UPF1, RNA helicase and ATPase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 18831938
Gene end: 18868236
  
Corresponding Affymetrix probe sets: 208947_s_at (Human Genome U133 Plus 2.0 Array)   211168_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262803
Ensembl peptide - ENSP00000470142
NCBI entrez gene - 5976     See in Manteia.
OMIM - 601430
RefSeq - XM_017027106
RefSeq - NM_001297549
RefSeq - NM_002911
RefSeq - XM_017027105
RefSeq Peptide - NP_001284478
RefSeq Peptide - NP_002902
swissprot - A0A024R7L8
swissprot - Q92900
swissprot - A0A024R7L5
Ensembl - ENSG00000005007
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 upf1ENSDARG00000016302Danio rerio
 UPF1ENSGALG00000003220Gallus gallus
 Upf1ENSMUSG00000058301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HELZ / P42694 / helicase with zinc fingerENSG0000019826518
HELZ2 / Q9BYK8 / helicase with zinc finger 2ENSG0000013058917
Q9BXT6 / MOV10L1 / Mov10 RISC complex RNA helicase like 1ENSG0000007314616
MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicaseENSG0000015536316


Protein motifs (from Interpro)
Interpro ID Name
 IPR006935  Helicase/UvrB, N-terminal
 IPR018999  RNA helicase UPF1, UPF2-interacting domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay IMP
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006449 regulation of translational termination NAS
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IEA
 biological_processGO:0032201 telomere maintenance via semi-conservative replication IDA
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0044770 cell cycle phase transition IMP
 biological_processGO:0061014 positive regulation of mRNA catabolic process IMP
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IMP
 biological_processGO:0071044 histone mRNA catabolic process IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035145 exon-exon junction complex IDA
 cellular_componentGO:0044530 supraspliceosomal complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding NAS
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IDA
 molecular_functionGO:0004386 helicase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105771 SMG9 / Q9H0W8 / SMG9, nonsense mediated mRNA decay factor  / complex / reaction
 ENSG00000167447 SMG8 / Q8ND04 / SMG8, nonsense mediated mRNA decay factor  / complex / reaction
 ENSG00000157106 SMG1 / Q96Q15 / SMG1, nonsense mediated mRNA decay associated PI3K related kinase  / complex / reaction






 

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