ENSG00000157106


Homo sapiens

Features
Gene ID: ENSG00000157106
  
Biological name :SMG1
  
Synonyms : Q96Q15 / SMG1 / SMG1, nonsense mediated mRNA decay associated PI3K related kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p12.3
Gene start: 18804853
Gene end: 18926454
  
Corresponding Affymetrix probe sets: 1558534_at (Human Genome U133 Plus 2.0 Array)   210057_at (Human Genome U133 Plus 2.0 Array)   224842_at (Human Genome U133 Plus 2.0 Array)   231989_s_at (Human Genome U133 Plus 2.0 Array)   237464_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458558
Ensembl peptide - ENSP00000458380
Ensembl peptide - ENSP00000460854
Ensembl peptide - ENSP00000484278
Ensembl peptide - ENSP00000481150
Ensembl peptide - ENSP00000402515
Ensembl peptide - ENSP00000432825
Ensembl peptide - ENSP00000455453
Ensembl peptide - ENSP00000455861
Ensembl peptide - ENSP00000456025
Ensembl peptide - ENSP00000456259
NCBI entrez gene - 23049     See in Manteia.
OMIM - 607032
RefSeq - XM_017023067
RefSeq - NM_015092
RefSeq - XM_005255182
RefSeq - XM_005255183
RefSeq - XM_005255184
RefSeq - XM_011545769
RefSeq - XM_011545770
RefSeq - XM_017023066
RefSeq Peptide - NP_055907
swissprot - J3KRA9
swissprot - A0A087WXM7
swissprot - Q96Q15
swissprot - E9PNP6
swissprot - A0A087X1K8
swissprot - H3BPS6
swissprot - H3BQN7
swissprot - H3BR09
swissprot - I3L0W2
swissprot - I3L400
swissprot - I3L144
Ensembl - ENSG00000157106
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smg1ENSDARG00000054570Danio rerio
 SMG1ENSGALG00000006829Gallus gallus
 Smg1ENSMUSG00000030655Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTOR / P42345 / mechanistic target of rapamycin kinaseENSG0000019879312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR014009  PIK-related kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR031559  Serine/threonine-protein kinase SMG1
 IPR035175  Serine/threonine-protein kinase SMG1, N-terminal
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation TAS
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IDA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005007 UPF1 / Q92900 / UPF1, RNA helicase and ATPase  / reaction / complex
 ENSG00000167447 SMG8 / Q8ND04 / SMG8, nonsense mediated mRNA decay factor  / complex
 ENSG00000105771 SMG9 / Q9H0W8 / SMG9, nonsense mediated mRNA decay factor  / complex






 

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