ENSG00000130589


Homo sapiens

Features
Gene ID: ENSG00000130589
  
Biological name :HELZ2
  
Synonyms : helicase with zinc finger 2 / HELZ2 / Q9BYK8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.33
Gene start: 63558086
Gene end: 63574239
  
Corresponding Affymetrix probe sets: 228230_at (Human Genome U133 Plus 2.0 Array)   232517_s_at (Human Genome U133 Plus 2.0 Array)   232518_at (Human Genome U133 Plus 2.0 Array)   232787_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393257
Ensembl peptide - ENSP00000417401
NCBI entrez gene - 85441     See in Manteia.
OMIM - 611265
RefSeq - NM_001037335
RefSeq - NM_033405
RefSeq Peptide - NP_001032412
RefSeq Peptide - NP_208384
swissprot - Q9BYK8
Ensembl - ENSG00000130589
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL935128.1ENSDARG00000012446Danio rerio
 HELZ2ENSGALG00000006138Gallus gallus
 Helz2ENSMUSG00000027580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HELZ / P42694 / helicase with zinc fingerENSG0000019826518
UPF1 / Q92900 / UPF1, RNA helicase and ATPaseENSG000000050077
MOV10 / Q9HCE1 / Mov10 RISC complex RNA helicaseENSG000001553637
Q9BXT6 / MOV10L1 / Mov10 RISC complex RNA helicase like 1ENSG000000731467


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031191  Helicase with zinc finger domain 2
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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