ENSMUSG00000027580


Mus musculus

Features
Gene ID: ENSMUSG00000027580
  
Biological name :Helz2
  
Synonyms : E9QAM5 / Helicase with zinc finger domain 2 / Helz2
  
Possible biological names infered from orthology : helicase with zinc finger 2 / Q9BYK8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181227615
Gene end: 181242027
  
Corresponding Affymetrix probe sets: 10490632 (MoGene1.0st)   1435454_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091756
Ensembl peptide - ENSMUSP00000112917
Ensembl peptide - ENSMUSP00000104459
NCBI entrez gene - 229003     See in Manteia.
MGI - MGI:2385169
RefSeq - XM_006500601
RefSeq - NM_183162
RefSeq - XM_006500599
RefSeq Peptide - NP_898985
swissprot - E9QAM5
swissprot - A2AS03
swissprot - A2AS05
Ensembl - ENSMUSG00000027580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL935128.1ENSDARG00000012446Danio rerio
 HELZ2ENSGALG00000006138Gallus gallus
 HELZ2ENSG00000130589Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Helz / Q6DFV5 / Probable helicase with zinc finger domain / P42694* / helicase with zinc finger*ENSMUSG0000002072117
Upf1 / Q9EPU0 / UPF1 regulator of nonsense transcripts homolog (yeast) / Q92900* / UPF1, RNA helicase and ATPase*ENSMUSG000000583017
Mov10l1 / Mov10 RISC complex RNA helicase like 1 / Q9BXT6*ENSMUSG000000153657
Mov10 / P23249 / Putative helicase MOV-10 / Q9HCE1* / Mov10 RISC complex RNA helicase*ENSMUSG000000022276


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031191  Helicase with zinc finger domain 2
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004848 abnormal liver size "anomaly in the average size of the liver " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Wee1tm1Cxd/Wee1tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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