ENSMUSG00000038374


Mus musculus

Features
Gene ID: ENSMUSG00000038374
  
Biological name :Rbm8a
  
Synonyms : Q9CWZ3 / Rbm8a / RNA-binding protein 8A
  
Possible biological names infered from orthology : Q9Y5S9 / RNA binding motif protein 8A
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96629933
Gene end: 96633791
  
Corresponding Affymetrix probe sets: 10494452 (MoGene1.0st)   1418119_at (Mouse Genome 430 2.0 Array)   1418120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142699
Ensembl peptide - ENSMUSP00000143346
Ensembl peptide - ENSMUSP00000143190
Ensembl peptide - ENSMUSP00000044548
NCBI entrez gene - 60365     See in Manteia.
MGI - MGI:1913129
RefSeq - NM_001102407
RefSeq - NM_025875
RefSeq Peptide - NP_001095877
RefSeq Peptide - NP_080151
swissprot - Q9CWZ3
swissprot - A0A0G2JEA9
swissprot - A0A0G2JFX7
Ensembl - ENSMUSG00000038374
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbm8aENSDARG00000016516Danio rerio
 RBM8AENSG00000265241Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm8a2 / RBM8A* / Q9Y5S9* / RNA binding motif protein 8A*ENSMUSG0000007818497


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR008111  RNA-binding motif protein 8
 IPR033744  RBM8, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome ISO
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035145 exon-exon junction complex ISO
 cellular_componentGO:0071013 catalytic step 2 spliceosome ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0011724 ectopic cortical neuron "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0013227 small brain ventricles "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020069 decreased neocortex size "size reduction or truncation of the neocortex" [GOC:NV]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020388 decreased radial glial cell number "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020392 abnormal radial glial cell apoptosis "change in the timing or the number of radial glial cells undergoing programmed cell death" [MGI:anna, PMID:25948253]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

 MP:0020393 increased neuronal precursor proliferation "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rbm8atm1Dlsi/Rbm8a+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078676 Casc3 / Q8K3W3 / Protein CASC3 / O15234* / cancer susceptibility 3*  / complex
 ENSMUSG00000028609 Magoh / P61327 / Protein mago nashi homolog / P61326* / mago homolog, exon junction complex core component*  / complex
 ENSMUSG00000038398 Upf3a / UPF3 regulator of nonsense transcripts homolog A (yeast) / Q9H1J1* / UPF3A, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000043241 Upf2 / UPF2 regulator of nonsense transcripts homolog (yeast) / Q9HAU5* / UPF2, regulator of nonsense mediated mRNA decay*  / complex
 ENSMUSG00000034681 Rnps1 / Q99M28 / RNA-binding protein with serine-rich domain 1 / Q15287*  / complex
 ENSMUSG00000025580 Eif4a3 / Q91VC3 / Eukaryotic initiation factor 4A-III Eukaryotic initiation factor 4A-III, N-terminally processed / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000094973 Gm8994 / EIF4A3* / P38919* / eukaryotic translation initiation factor 4A3*  / complex
 ENSMUSG00000036572 Upf3b / UPF3 regulator of nonsense transcripts homolog B (yeast) / Q9BZI7* / UPF3B, regulator of nonsense mediated mRNA decay*  / complex






 

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