ENSG00000151461


Homo sapiens

Features
Gene ID: ENSG00000151461
  
Biological name :UPF2
  
Synonyms : Q9HAU5 / UPF2 / UPF2, regulator of nonsense mediated mRNA decay
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p14
Gene start: 11920022
Gene end: 12043170
  
Corresponding Affymetrix probe sets: 203519_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348708
Ensembl peptide - ENSP00000350221
Ensembl peptide - ENSP00000380244
NCBI entrez gene - 26019     See in Manteia.
OMIM - 605529
RefSeq - XM_017016034
RefSeq - NM_015542
RefSeq - NM_080599
RefSeq Peptide - NP_542166
RefSeq Peptide - NP_056357
swissprot - Q9HAU5
Ensembl - ENSG00000151461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068469.1ENSDARG00000111388Danio rerio
 UPF2ENSGALG00000033772Gallus gallus
 Upf2ENSMUSG00000043241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003890  MIF4G-like, type 3
 IPR007193  Up-frameshift suppressor 2
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0031100 animal organ regeneration IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IBA
 cellular_componentGO:0035145 exon-exon junction complex IDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IDA


Pathways (from Reactome)
Pathway description
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108349 CASC3 / O15234 / cancer susceptibility 3  / complex
 ENSG00000125351 UPF3B / Q9BZI7 / UPF3B, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000141543 EIF4A3 / P38919 / eukaryotic translation initiation factor 4A3  / complex
 ENSG00000111196 MAGOHB / Q96A72 / mago homolog B, exon junction complex core component  / complex
 ENSG00000169062 UPF3A / Q9H1J1 / UPF3A, regulator of nonsense mediated mRNA decay  / complex
 ENSG00000205937 RNPS1 / Q15287 / RNA binding protein with serine rich domain 1  / complex
 ENSG00000162385 MAGOH / P61326 / mago homolog, exon junction complex core component  / complex
 ENSG00000265241 RBM8A / Q9Y5S9 / RNA binding motif protein 8A  / complex






 

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