ENSGALG00000008520


Gallus gallus

Features
Gene ID: ENSGALG00000008520
  
Biological name :EIF4G1
  
Synonyms : EIF4G1 / eukaryotic translation initiation factor 4 gamma 1
  
Possible biological names infered from orthology : Q04637 / Q6NZJ6
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 15944055
Gene end: 15965743
  
Corresponding Affymetrix probe sets: Gga.6897.1.S1_at (Chicken Array)   GgaAffx.5365.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044814
Ensembl peptide - ENSGALP00000054947
Ensembl peptide - ENSGALP00000048312
Ensembl peptide - ENSGALP00000047498
Ensembl peptide - ENSGALP00000013862
NCBI entrez gene - 424953     See in Manteia.
RefSeq - XM_015291543
RefSeq - XM_015291539
RefSeq - XM_015291540
RefSeq - XM_015291541
RefSeq - XM_015291542
RefSeq - XM_015291528
RefSeq - XM_015291529
RefSeq - XM_015291530
RefSeq - XM_015291531
RefSeq - XM_015291532
RefSeq - XM_015291533
RefSeq - XM_015291534
RefSeq - XM_015291535
RefSeq - XM_015291536
RefSeq - XM_015291537
RefSeq - XM_015291538
swissprot - E1BSG5
swissprot - A0A1D5PPZ0
swissprot - A0A1D5P6I5
swissprot - A0A1D5P490
Ensembl - ENSGALG00000008520
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01061894.1ENSDARG00000116712Danio rerio
 eif4g1aENSDARG00000006200Danio rerio
 EIF4G1ENSG00000114867Homo sapiens
 Eif4g1ENSMUSG00000045983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4G3 / eukaryotic translation initiation factor 4 gamma 3 / O43432* / Mus musculus eukaryotic translation initiation factor 4 gamma, 3 (Eif4g3), transcript variant 4, mRNA.*ENSGALG0000001008447
EIF4G2 / eukaryotic translation initiation factor 4 gamma 2 isoform 1 / P78344* / eukaryotic translation initiation factor 4 gamma 2* / eukaryotic translation initiation factor 4 gamma 2 isoform 2 *ENSGALG0000000558715


Protein motifs (from Interpro)
Interpro ID Name
 IPR003307  W2 domain
 IPR003890  MIF4G-like, type 3
 IPR003891  Initiation factor eIF-4 gamma, MA3
 IPR016021  MIF4G-like domain superfamily
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006446 regulation of translational initiation IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034645 cellular macromolecule biosynthetic process IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:1905537 positive regulation of eukaryotic translation initiation factor 4F complex assembly IEA
 biological_processGO:1905606 regulation of presynapse assembly IEA
 biological_processGO:1905612 positive regulation of mRNA cap binding IEA
 biological_processGO:1905618 positive regulation of miRNA mediated inhibition of translation IEA
 biological_processGO:1905696 regulation of polysome binding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008135 translation factor activity, RNA binding IEA
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001313 EIF4H / eukaryotic translation initiation factor 4H / Q15056* / Q9WUK2*  / complex
 ENSGALG00000002087 NCBP1 / Q5ZJZ6 / Nuclear cap-binding protein subunit 1 / Q09161* / Q3UYV9*  / complex
 ENSGALG00000005198 RPS6KB1 / ribosomal protein S6 kinase beta-1 / P23443* / Q8BSK8* / ribosomal protein S6 kinase B1* / ribosomal protein S6 kinase, polypeptide 1*  / reaction
 ENSGALG00000033196 EIF2S2 / eukaryotic translation initiation factor 2 subunit beta / P20042* / Q99L45* / Eukaryotic translation initiation factor 2 subunit 2 *  / reaction
 ENSGALG00000009565 EIF2S1 / Q5ZLX2 / Eukaryotic translation initiation factor 2 subunit 1 / Q6ZWX6* / P05198* / eukaryotic translation initiation factor 2 subunit alpha*  / reaction
 ENSGALG00000006843 NCBP2 / A6PVI3* / NCBP2L* / P52298* / Q9CQ49* / nuclear cap binding protein subunit 2* / nuclear cap binding protein subunit 2 like*  / complex
 ENSGALG00000042112 EIF4E / eukaryotic translation initiation factor 4E / P06730* / P63073*  / complex






 

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