ENSGALG00000042112


Gallus gallus

Features
Gene ID: ENSGALG00000042112
  
Biological name :EIF4E
  
Synonyms : EIF4E / eukaryotic translation initiation factor 4E
  
Possible biological names infered from orthology : P06730 / P63073
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 60278552
Gene end: 60297364
  
Corresponding Affymetrix probe sets: Gga.13334.1.S1_at (Chicken Array)   Gga.19080.1.S1_at (Chicken Array)   Gga.3595.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054861
NCBI entrez gene - 422703     See in Manteia.
RefSeq - XM_015285643
swissprot - A0A1D5PPQ7
Ensembl - ENSGALG00000042112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4eaENSDARG00000077012Danio rerio
 eif4ebENSDARG00000013274Danio rerio
 EIF4EENSG00000151247Homo sapiens
 Eif4eENSMUSG00000028156Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4E1B / eukaryotic translation initiation factor 4E family member 1B / A6NMX2* / Q3UTA9* / Eukaryotic translation initiation factor 4E type 1B *ENSGALG0000002603768
EIF4E2 / eukaryotic translation initiation factor 4E family member 2 / O60573* / Q8BMB3* / Mus musculus eukaryotic translation initiation factor 4E member 2 (Eif4e2), transcript variant 4, mRNA.*ENSGALG0000000791933
EIF4E3 / eukaryotic translation initiation factor 4E family member 3 / Q8N5X7* / Q9DBB5* / Eukaryotic translation initiation factor 4E type 3 *ENSGALG0000000778024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001040  Translation Initiation factor eIF- 4e
 IPR019770  Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
 IPR023398  Translation Initiation factor eIF- 4e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0016281 eukaryotic translation initiation factor 4F complex IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0033391 chromatoid body IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031370 eukaryotic initiation factor 4G binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001313 EIF4H / eukaryotic translation initiation factor 4H / Q15056* / Q9WUK2*  / complex
 ENSGALG00000003205 EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1 / Q13541* / Q60876*  / complex
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / reaction
 ENSGALG00000009565 EIF2S1 / Q5ZLX2 / Eukaryotic translation initiation factor 2 subunit 1 / Q6ZWX6* / P05198* / eukaryotic translation initiation factor 2 subunit alpha*  / reaction
 ENSGALG00000008520 EIF4G1 / eukaryotic translation initiation factor 4 gamma 1 / Q04637* / Q6NZJ6*  / complex
 ENSGALG00000033196 EIF2S2 / eukaryotic translation initiation factor 2 subunit beta / P20042* / Q99L45* / Eukaryotic translation initiation factor 2 subunit 2 *  / reaction






 

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