ENSGALG00000003205


Gallus gallus

Features
Gene ID: ENSGALG00000003205
  
Biological name :EIF4EBP1
  
Synonyms : EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1
  
Possible biological names infered from orthology : Q13541 / Q60876
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 2270716
Gene end: 2275385
  
Corresponding Affymetrix probe sets: Gga.9583.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005068
NCBI entrez gene - 426773     See in Manteia.
RefSeq - XM_424384
swissprot - E1C115
Ensembl - ENSGALG00000003205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4ebp1ENSDARG00000043608Danio rerio
 Q13541ENSG00000187840Homo sapiens
 Q60876ENSMUSG00000031490Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF4EBP2 / Gallus gallus eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2), mRNA. / P70445* / Q13542* / eukaryotic translation initiation factor 4E binding protein 2*ENSGALG0000003790449


Protein motifs (from Interpro)
Interpro ID Name
 IPR008606  Eukaryotic translation initiation factor 4E binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0002192 IRES-dependent translational initiation of linear mRNA IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045947 negative regulation of translational initiation IBA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IBA
 molecular_functionGO:0030371 translation repressor activity IEA


Pathways (from Reactome)
Pathway description
mTORC1-mediated signalling
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042112 EIF4E / eukaryotic translation initiation factor 4E / P06730* / P63073*  / complex
 ENSGALG00000003339 MTOR / mechanistic target of rapamycin kinase / P42345* / Q9JLN9* / Serine/threonine-protein kinase mTOR *  / reaction






 

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