ENSMUSG00000031490


Mus musculus

Features
Gene ID: ENSMUSG00000031490
  
Biological name :Eif4ebp1
  
Synonyms : Eif4ebp1 / eukaryotic translation initiation factor 4E binding protein 1 / Q60876
  
Possible biological names infered from orthology : Q13541
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 27260329
Gene end: 27276674
  
Corresponding Affymetrix probe sets: 10571162 (MoGene1.0st)   1417562_at (Mouse Genome 430 2.0 Array)   1417563_at (Mouse Genome 430 2.0 Array)   1434976_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033880
NCBI entrez gene - 13685     See in Manteia.
MGI - MGI:103267
RefSeq - NM_007918
RefSeq Peptide - NP_031944
swissprot - Q60876
Ensembl - ENSMUSG00000031490
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4ebp1ENSDARG00000043608Danio rerio
 EIF4EBP1ENSGALG00000003205Gallus gallus
 Q13541ENSG00000187840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70445 / Eif4ebp2 / eukaryotic translation initiation factor 4E binding protein 2 / Q13542*ENSMUSG0000002009159
Q80VV3 / Eif4ebp3 / eukaryotic translation initiation factor 4E binding protein 3 / O60516*ENSMUSG0000009026447


Protein motifs (from Interpro)
Interpro ID Name
 IPR008606  Eukaryotic translation initiation factor 4E binding
 IPR037582  Eukaryotic translation initiation factor 4E-binding protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0002192 IRES-dependent translational initiation of linear mRNA IDA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045947 negative regulation of translational initiation ISO
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:1990928 response to amino acid starvation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding ISO
 molecular_functionGO:0030371 translation repressor activity IEA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Eif4ebp1tm1Pjb/Eif4ebp1tm1Pjb
Genetic Background: involves: 129P2/OlaHsd

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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