ENSMUSG00000020091


Mus musculus

Features
Gene ID: ENSMUSG00000020091
  
Biological name :Eif4ebp2
  
Synonyms : Eif4ebp2 / eukaryotic translation initiation factor 4E binding protein 2 / P70445
  
Possible biological names infered from orthology : Q13542
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 61428491
Gene end: 61452661
  
Corresponding Affymetrix probe sets: 10369474 (MoGene1.0st)   1417084_at (Mouse Genome 430 2.0 Array)   1436158_at (Mouse Genome 430 2.0 Array)   1437733_at (Mouse Genome 430 2.0 Array)   1455575_at (Mouse Genome 430 2.0 Array)   1456613_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020288
Ensembl peptide - ENSMUSP00000131952
NCBI entrez gene - 13688     See in Manteia.
MGI - MGI:109198
RefSeq - XM_017313793
RefSeq - NM_010124
RefSeq - XM_017313792
RefSeq Peptide - NP_034254
swissprot - Q3UFP6
swissprot - P70445
Ensembl - ENSMUSG00000020091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif4ebp2ENSDARG00000031819Danio rerio
 EIF4EBP2ENSGALG00000037904Gallus gallus
 Q13542ENSG00000148730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60876 / Eif4ebp1 / eukaryotic translation initiation factor 4E binding protein 1 / Q13541*ENSMUSG0000003149058
Q80VV3 / Eif4ebp3 / eukaryotic translation initiation factor 4E binding protein 3 / O60516*ENSMUSG0000009026444


Protein motifs (from Interpro)
Interpro ID Name
 IPR008606  Eukaryotic translation initiation factor 4E binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation TAS
 biological_processGO:0007613 memory IMP
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0031929 TOR signaling IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0045947 negative regulation of translational initiation IMP
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IMP
 molecular_functionGO:0030371 translation repressor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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