ENSMUSG00000029478


Mus musculus

Features
Gene ID: ENSMUSG00000029478
  
Biological name :Ncor2
  
Synonyms : Ncor2 / Nuclear receptor corepressor 2 / Q9WU42
  
Possible biological names infered from orthology : Q9Y618
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.1
Gene start: 125017153
Gene end: 125179219
  
Corresponding Affymetrix probe sets: 10533875 (MoGene1.0st)   1448893_at (Mouse Genome 430 2.0 Array)   1451841_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115776
Ensembl peptide - ENSMUSP00000107033
Ensembl peptide - ENSMUSP00000117098
Ensembl peptide - ENSMUSP00000142862
Ensembl peptide - ENSMUSP00000142725
Ensembl peptide - ENSMUSP00000121588
Ensembl peptide - ENSMUSP00000117813
Ensembl peptide - ENSMUSP00000055954
Ensembl peptide - ENSMUSP00000083250
Ensembl peptide - ENSMUSP00000107024
Ensembl peptide - ENSMUSP00000107025
Ensembl peptide - ENSMUSP00000107029
NCBI entrez gene - 20602     See in Manteia.
MGI - MGI:1337080
RefSeq - XM_017320762
RefSeq - XM_011240830
RefSeq - XM_011240831
RefSeq - XM_011240832
RefSeq - XM_011240833
RefSeq - XM_011240834
RefSeq - XM_011240836
RefSeq - XM_017320754
RefSeq - XM_017320755
RefSeq - XM_017320756
RefSeq - XM_017320757
RefSeq - XM_017320758
RefSeq - XM_017320759
RefSeq - XM_017320760
RefSeq - XM_017320761
RefSeq - NM_001253904
RefSeq - NM_001253905
RefSeq - NM_011424
RefSeq - XM_006504282
RefSeq - XM_006504283
RefSeq - XM_006504284
RefSeq - XM_011240820
RefSeq - XM_011240821
RefSeq - XM_011240822
RefSeq - XM_011240823
RefSeq - XM_011240824
RefSeq - XM_011240825
RefSeq - XM_011240826
RefSeq - XM_011240827
RefSeq - XM_011240828
RefSeq - XM_011240829
RefSeq Peptide - NP_035554
RefSeq Peptide - NP_001240833
RefSeq Peptide - NP_001240834
swissprot - D3Z2J5
swissprot - F6SK53
swissprot - F6YAU7
swissprot - F6Z4B2
swissprot - E9Q9V3
swissprot - A0A0G2JEQ5
swissprot - Q9WU42
swissprot - A0A0G2JED1
swissprot - F8VQL9
swissprot - E9Q701
swissprot - E9PY55
Ensembl - ENSMUSG00000029478
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncor2ENSDARG00000000966Danio rerio
 NCOR2ENSGALG00000003120Gallus gallus
 NCOR2ENSG00000196498Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncor1 / nuclear receptor co-repressor 1 / O75376* / nuclear receptor corepressor 1*ENSMUSG0000001850142
Rcor3 / Q6PGA0 / REST corepressor 3 / Q9P2K3*ENSMUSG000000373955
Rcor2 / Q8C796 / REST corepressor 2 / Q8IZ40*ENSMUSG000000249685
Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*ENSMUSG000000378963


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR031557  N-CoR, GPS2-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0050872 white fat cell differentiation IMP
 biological_processGO:0060509 type I pneumocyte differentiation IMP
 biological_processGO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter ISO
 biological_processGO:0090312 positive regulation of protein deacetylation IDA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005112 Notch binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0016922 nuclear receptor binding IBA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
HDACs deacetylate histones
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Foxp1Gt(S17-4A1)Sor/Foxp1+,Ncor2tm1Rsd/Ncor2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxp1Gt(S17-4A1)Sor/Foxp1+,Ncor2tm1Rsd/Ncor2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
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Allelic Composition: Ncor2tm1Rev/Ncor2tm1Rev
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000029050 Ski / SKI proto-oncogene / P12755*  / reaction / complex
 ENSMUSG00000027660 Skil / Q60665 / SKI-like / P12757* / SKI like proto-oncogene*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction






 

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