ENSMUSG00000027660


Mus musculus

Features
Gene ID: ENSMUSG00000027660
  
Biological name :Skil
  
Synonyms : Q60665 / Skil / SKI-like
  
Possible biological names infered from orthology : P12757 / SKI like proto-oncogene
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 31095058
Gene end: 31122577
  
Corresponding Affymetrix probe sets: 10491300 (MoGene1.0st)   1422054_a_at (Mouse Genome 430 2.0 Array)   1452214_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029194
Ensembl peptide - ENSMUSP00000113054
Ensembl peptide - ENSMUSP00000113256
Ensembl peptide - ENSMUSP00000123522
Ensembl peptide - ENSMUSP00000112413
NCBI entrez gene - 20482     See in Manteia.
MGI - MGI:106203
RefSeq - XM_006535427
RefSeq - NM_001039090
RefSeq - NM_001271772
RefSeq - NM_011386
RefSeq Peptide - NP_035516
RefSeq Peptide - NP_001034179
RefSeq Peptide - NP_001258701
swissprot - D3YYG2
swissprot - D3Z7C5
swissprot - Q3TB81
swissprot - Q60665
Ensembl - ENSMUSG00000027660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skilaENSDARG00000023933Danio rerio
 skilbENSDARG00000022904Danio rerio
 SKILENSGALG00000009356Gallus gallus
 SKILENSG00000136603Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ski / SKI proto-oncogene / P12755*ENSMUSG0000002905040
Skor1 / Q8BX46 / SKI family transcriptional corepressor 1 / P84550*ENSMUSG0000002224520
Skor2 / A7M7C7 / SKI family transcriptional corepressor 2 / Q2VWA4*ENSMUSG0000009151918


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028373  Ski-related oncogene Sno
 IPR037000  Ski-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001825 blastocyst formation IMP
 biological_processGO:0002260 lymphocyte homeostasis IMP
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007519 skeletal muscle tissue development ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0045596 negative regulation of cell differentiation IDA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0070207 protein homotrimerization ISO
 biological_processGO:0070208 protein heterotrimerization ISO
 biological_processGO:0070306 lens fiber cell differentiation IDA
 biological_processGO:0070848 response to growth factor ISO
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0046332 SMAD binding IBA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

 MP:0001881 abnormal mammary gland physiology "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Hand1tm1Jcc/Hand1tm1Jcc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

 MP:0012075 impaired mammary gland growth during pregnancy "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
Show

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0013781 abnormal mammary gland luminal epithelium morphology "any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, ISBN:8793237073, MGI:Anna]
Show

Allelic Composition: Ccna2tm1Sot/Ccna2tm1Sot
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000029478 Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*  / complex / reaction






 

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