Manteia - Molecule gene

ENSMUSG00000091519

Mus musculus

Features

Gene ID:	ENSMUSG00000091519

Biological name :	Skor2

Synonyms :	A7M7C7 / SKI family transcriptional corepressor 2 / Skor2

Possible biological names infered from orthology :	Q2VWA4

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	E3
Gene start:	76856405
Gene end:	76900342

Corresponding Affymetrix probe sets:	10456781 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000132338 NCBI entrez gene - 664805 See in Manteia. MGI - MGI:3645984 RefSeq - NM_001109743 RefSeq - XM_006526436 RefSeq Peptide - NP_001103213 swissprot - A7M7C7 Ensembl - ENSMUSG00000091519

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
zgc:153395	ENSDARG00000063614	Danio rerio
	ENSGALG00000045544	Gallus gallus
SKOR2	ENSG00000215474	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Skor1 / Q8BX46 / SKI family transcriptional corepressor 1 / P84550*	ENSMUSG00000022245	39
Ski / SKI proto-oncogene / P12755*	ENSMUSG00000029050	15
Skil / Q60665 / SKI-like / P12757* / SKI like proto-oncogene*	ENSMUSG00000027660	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR003380	SKI/SNO/DAC domain
IPR009061	Putative DNA-binding domain superfamily
IPR010919	SAND-like domain superfamily
IPR014890	c-SKI SMAD4-binding domain
IPR023216	Transcription regulator SKI/SnoN
IPR028376	SKI family transcriptional corepressor 2
IPR037000	Ski-like, DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0021587	cerebellum morphogenesis	IMP
biological_process	GO:0021702	cerebellar Purkinje cell differentiation	IMP
biological_process	GO:0021936	regulation of cerebellar granule cell precursor proliferation	IMP
biological_process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IEA
biological_process	GO:0030514	negative regulation of BMP signaling pathway	IGI
biological_process	GO:0045596	negative regulation of cell differentiation	IBA
biological_process	GO:0045880	positive regulation of smoothened signaling pathway	IMP
biological_process	GO:0048468	cell development	IMP
biological_process	GO:0048814	regulation of dendrite morphogenesis	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISO
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003714	transcription corepressor activity	IDA
molecular_function	GO:0042826	histone deacetylase binding	IPI
molecular_function	GO:0046332	SMAD binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Camk2a^tm1Kub/Camk2a^tm1Kub Genetic Background: involves: 129 * C57BL/6
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Camk2a^tm1Kub/Camk2a^tm1Kub Genetic Background: involves: 129 * C57BL/6
MP:0000890	thin cerebellar molecular layer	"reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N
MP:0001053	abnormal neuromuscular synapse	"malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA3Ove}/Skor2^{Tn(sb-Tyr)1799B.CA3Ove} Genetic Background: involves: FVB/N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA3Ove}/Skor2^{Tn(sb-Tyr)1799B.CA3Ove} Genetic Background: involves: FVB/N
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA3Ove}/Skor2^{Tn(sb-Tyr)1799B.CA3Ove} Genetic Background: involves: FVB/N
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA3Ove}/Skor2^{Tn(sb-Tyr)1799B.CA3Ove} Genetic Background: involves: FVB/N
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0006097	abnormal cerebellar lobule formation	"anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0008579	abnormal Purkinje cell differentiation	"atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0009719	reduced cerebellar foliation	"the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N
MP:0010008	abnormal Purkinje cell migration	"defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Skor2^tm1Yono/Skor2^tm1Yono Genetic Background: involves: 129 * C57BL/6
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA3Ove}/Skor2^{Tn(sb-Tyr)1799B.CA3Ove} Genetic Background: involves: FVB/N
MP:0013551	decreased cerebellar granule cell precursor proliferation	"reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]	Show Allelic Composition: Scrib^tm1.2Phum/Scrib⁺ Genetic Background: involves: FVB/N Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7Ove}/Skor2^{Tn(sb-Tyr)1799B.CA7Ove} Genetic Background: involves: FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr