ENSG00000215474


Homo sapiens

Features
Gene ID: ENSG00000215474
  
Biological name :SKOR2
  
Synonyms : Q2VWA4 / SKI family transcriptional corepressor 2 / SKOR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.1
Gene start: 47206322
Gene end: 47251603
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000483333
Ensembl peptide - ENSP00000383255
Ensembl peptide - ENSP00000414750
NCBI entrez gene - 652991     See in Manteia.
OMIM - 617138
RefSeq - XM_006722525
RefSeq - NM_001037802
RefSeq - NM_001278063
RefSeq Peptide - NP_001032891
RefSeq Peptide - NP_001264992
swissprot - Q2VWA4
swissprot - A0A087X0E6
Ensembl - ENSG00000215474
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:153395ENSDARG00000063614Danio rerio
 ENSGALG00000045544Gallus gallus
 Skor2ENSMUSG00000091519Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SKOR1 / P84550 / SKI family transcriptional corepressor 1ENSG0000018877933
SKI / P12755 / SKI proto-oncogeneENSG0000015793315
SKIL / P12757 / SKI like proto-oncogeneENSG0000013660312


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028376  SKI family transcriptional corepressor 2
 IPR037000  Ski-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0021587 cerebellum morphogenesis IEA
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IEA
 biological_processGO:0021936 regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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