ENSG00000136603


Homo sapiens

Features
Gene ID: ENSG00000136603
  
Biological name :SKIL
  
Synonyms : P12757 / SKIL / SKI like proto-oncogene
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.2
Gene start: 170357678
Gene end: 170396835
  
Corresponding Affymetrix probe sets: 206675_s_at (Human Genome U133 Plus 2.0 Array)   215889_at (Human Genome U133 Plus 2.0 Array)   217591_at (Human Genome U133 Plus 2.0 Array)   225227_at (Human Genome U133 Plus 2.0 Array)   232379_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417670
Ensembl peptide - ENSP00000415243
Ensembl peptide - ENSP00000418237
Ensembl peptide - ENSP00000259119
Ensembl peptide - ENSP00000400193
Ensembl peptide - ENSP00000406520
NCBI entrez gene - 6498     See in Manteia.
OMIM - 165340
RefSeq - XM_006713735
RefSeq - NM_001145097
RefSeq - NM_001145098
RefSeq - NM_001248008
RefSeq - NM_005414
RefSeq - XM_005247721
RefSeq Peptide - NP_001234937
RefSeq Peptide - NP_001138570
RefSeq Peptide - NP_001138569
RefSeq Peptide - NP_005405
swissprot - C9J8R9
swissprot - H7C4V3
swissprot - P12757
Ensembl - ENSG00000136603
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skilaENSDARG00000023933Danio rerio
 skilbENSDARG00000022904Danio rerio
 SKILENSGALG00000009356Gallus gallus
 SkilENSMUSG00000027660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SKI / P12755 / SKI proto-oncogeneENSG0000015793339
SKOR2 / Q2VWA4 / SKI family transcriptional corepressor 2ENSG0000021547418
SKOR1 / P84550 / SKI family transcriptional corepressor 1ENSG0000018877918


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028373  Ski-related oncogene Sno
 IPR037000  Ski-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000141027 NCOR1 / O75376 / nuclear receptor corepressor 1  / complex / reaction
 ENSG00000196498 NCOR2 / Q9Y618 / nuclear receptor corepressor 2  / complex / reaction






 

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