ENSGALG00000009356


Gallus gallus

Features
Gene ID: ENSGALG00000009356
  
Biological name :SKIL
  
Synonyms : SKIL / ski-like protein
  
Possible biological names infered from orthology : P12757 / Q60665 / SKI-like / SKI like proto-oncogene
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 19875560
Gene end: 19887827
  
Corresponding Affymetrix probe sets: Gga.645.1.S1_at (Chicken Array)   Gga.645.1.S1_s_at (Chicken Array)   Gga.645.1.S2_at (Chicken Array)   GgaAffx.20674.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015220
Ensembl peptide - ENSGALP00000055794
NCBI entrez gene - 396087     See in Manteia.
RefSeq - NM_205174
RefSeq Peptide - NP_990505
swissprot - F1P0N0
Ensembl - ENSGALG00000009356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skilaENSDARG00000023933Danio rerio
 skilbENSDARG00000022904Danio rerio
 SKILENSG00000136603Homo sapiens
 SkilENSMUSG00000027660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SKI / ski oncogene / P12755* / SKI proto-oncogene*ENSGALG0000000122939
SKOR1 / SKI family transcriptional corepressor 1 / P84550* / Q8BX46*ENSGALG0000002952117
SKOR2* / A7M7C7* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSGALG0000004554412


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028373  Ski-related oncogene Sno


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048666 neuron development IBA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IMP
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IMP
 molecular_functionGO:0046332 SMAD binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0070491 repressing transcription factor binding IMP


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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