ENSMUSG00000024968


Mus musculus

Features
Gene ID: ENSMUSG00000024968
  
Biological name :Rcor2
  
Synonyms : Q8C796 / Rcor2 / REST corepressor 2
  
Possible biological names infered from orthology : Q8IZ40
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 7267325
Gene end: 7275225
  
Corresponding Affymetrix probe sets: 10461057 (MoGene1.0st)   1417302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108996
Ensembl peptide - ENSMUSP00000114858
Ensembl peptide - ENSMUSP00000063335
NCBI entrez gene - 104383     See in Manteia.
MGI - MGI:1859854
RefSeq - NM_054048
RefSeq - XM_006526551
RefSeq - NM_001320554
RefSeq Peptide - NP_001307483
RefSeq Peptide - NP_473389
swissprot - A0A0R4J1I0
swissprot - Q8C796
swissprot - D3YUX3
Ensembl - ENSMUSG00000024968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcor2ENSDARG00000008278Danio rerio
 RCOR2ENSG00000167771Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rcor3 / Q6PGA0 / REST corepressor 3 / Q9P2K3*ENSMUSG0000003739559
Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*ENSMUSG0000003789641
Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*ENSMUSG0000002947824
Ncor1 / nuclear receptor co-repressor 1 / O75376* / nuclear receptor corepressor 1*ENSMUSG0000001850124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0017053 transcriptional repressor complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Rcor2tm1c(EUCOMM)Wtsi/Rcor2tm1c(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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