Manteia - Molecule gene

ENSMUSG00000018501

Mus musculus

Features

Gene ID:	ENSMUSG00000018501

Biological name :	Ncor1

Synonyms :	Ncor1 / nuclear receptor co-repressor 1

Possible biological names infered from orthology :	nuclear receptor corepressor 1 / O75376

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B2
Gene start:	62316426
Gene end:	62458541

Corresponding Affymetrix probe sets:	10386850 (MoGene1.0st) 1423200_at (Mouse Genome 430 2.0 Array) 1423201_at (Mouse Genome 430 2.0 Array) 1423202_a_at (Mouse Genome 430 2.0 Array) 1435914_at (Mouse Genome 430 2.0 Array) 1444760_at (Mouse Genome 430 2.0 Array) 1458103_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124175 Ensembl peptide - ENSMUSP00000124120 Ensembl peptide - ENSMUSP00000124698 Ensembl peptide - ENSMUSP00000125458 Ensembl peptide - ENSMUSP00000125317 Ensembl peptide - ENSMUSP00000018645 Ensembl peptide - ENSMUSP00000038900 Ensembl peptide - ENSMUSP00000068974 Ensembl peptide - ENSMUSP00000098627 Ensembl peptide - ENSMUSP00000098628 Ensembl peptide - ENSMUSP00000121806 Ensembl peptide - ENSMUSP00000122647 Ensembl peptide - ENSMUSP00000122654 Ensembl peptide - ENSMUSP00000123822 Ensembl peptide - ENSMUSP00000124045 NCBI entrez gene - 20185 See in Manteia. MGI - MGI:1349717 RefSeq - XM_017314391 RefSeq - XM_017314374 RefSeq - XM_017314375 RefSeq - XM_017314376 RefSeq - XM_017314377 RefSeq - XM_017314378 RefSeq - XM_017314379 RefSeq - XM_017314380 RefSeq - XM_017314381 RefSeq - XM_017314382 RefSeq - XM_017314383 RefSeq - XM_017314384 RefSeq - XM_017314385 RefSeq - XM_017314386 RefSeq - XM_017314387 RefSeq - XM_017314388 RefSeq - XM_017314389 RefSeq - XM_017314390 RefSeq - NM_001252313 RefSeq - NM_011308 RefSeq - NM_177229 RefSeq - XM_006532613 RefSeq - XM_006532614 RefSeq - XM_006532615 RefSeq - XM_006532616 RefSeq - XM_006532618 RefSeq - XM_006532619 RefSeq - XM_006532620 RefSeq - XM_006532621 RefSeq - XM_006532623 RefSeq - XM_006532624 RefSeq - XM_006532625 RefSeq - XM_006532626 RefSeq - XM_006532627 RefSeq - XM_006532628 RefSeq - XM_017314356 RefSeq - XM_017314357 RefSeq - XM_017314358 RefSeq - XM_017314359 RefSeq - XM_017314360 RefSeq - XM_017314361 RefSeq - XM_017314362 RefSeq - XM_017314363 RefSeq - XM_017314364 RefSeq - XM_017314365 RefSeq - XM_017314366 RefSeq - XM_017314367 RefSeq - XM_017314368 RefSeq - XM_017314369 RefSeq - XM_017314370 RefSeq - XM_017314371 RefSeq - XM_017314372 RefSeq - XM_017314373 RefSeq Peptide - NP_001239242 RefSeq Peptide - NP_035438 RefSeq Peptide - NP_796203 swissprot - F6TRR6 swissprot - F6TWR1 swissprot - F6U338 swissprot - F7C134 swissprot - E9Q2B2 swissprot - Q8BK32 swissprot - Q8CHB6 swissprot - E0CYX5 swissprot - Q3UV08 swissprot - Q5RIM6 swissprot - E9Q9Y2 swissprot - Q5RIN0 swissprot - E9Q8K6 swissprot - F6SFD2 Ensembl - ENSMUSG00000018501

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ncor1	ENSDARG00000035285	Danio rerio
NCOR1	ENSGALG00000004477	Gallus gallus
NCOR1	ENSG00000141027	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*	ENSMUSG00000029478	42
Rcor3 / Q6PGA0 / REST corepressor 3 / Q9P2K3*	ENSMUSG00000037395	6
Rcor2 / Q8C796 / REST corepressor 2 / Q8IZ40*	ENSMUSG00000024968	5
Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*	ENSMUSG00000037896	4

Protein motifs (from Interpro)

Interpro ID	Name
IPR001005	SANT/Myb domain
IPR009057	Homeobox-like domain superfamily
IPR017884	SANT domain
IPR031557	N-CoR, GPS2-interacting domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046329	negative regulation of JNK cascade	IEA
biological_process	GO:0051225	spindle assembly	IEA
biological_process	GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	IEA
biological_process	GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	IEA
biological_process	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	IEA
cellular_component	GO:0000118	histone deacetylase complex	IEA
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005876	spindle microtubule	IEA
cellular_component	GO:0016580	Sin3 complex	IEA
cellular_component	GO:0017053	transcriptional repressor complex	IEA
molecular_function	GO:0001102	RNA polymerase II activating transcription factor binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0035257	nuclear hormone receptor binding	IEA
molecular_function	GO:0042826	histone deacetylase binding	IEA

Pathways (from Reactome)

Pathway description

Downregulation of SMAD2/3:SMAD4 transcriptional activity

HDACs deacetylate histones

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx2^tm1Dra/Lhx2⁺,Lhx9^tm1Dodd/Lhx9^tm1Dodd,Robo3^tm1Matl/Robo3⁺ Genetic Background: Not Specified Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya,Smad2^tm1Xya/Smad2^tm1Xya,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000348	abnormal aerobic fitness	"any change in the metabolism resulting in an altered ability to do physical work; for example, alterations in running capacity" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya,Smad2^tm1Xya/Smad2^tm1Xya,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya,Smad2^tm1Xya/Smad2^tm1Xya,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya,Smad2^tm1Xya/Smad2^tm1Xya,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002575	increased circulating ketone body level	"greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0002596	abnormal hematocrit	"greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kif18a^tm1Zgwg/Kif18a^tm1Zgwg Genetic Background: either: 129-Kif18a^tm1Zgwg or (involves: 129 * C57BL/6J)
MP:0002801	abnormal long-term recognition memory	"defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0003081	abnormal soleus morphology	"anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0003082	abnormal gastrocnemius morphology	"anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0003461	abnormal response to novel object	"altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0003503	decreased activity of thyroid		Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0003915	increased left ventricle weight	"greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003948	abnormal gas homeostasis	"anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0005469	abnormal thyroxine level	"anomalous concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ncor1^tm1Anh/Ncor1^tm1Anh,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * DBA Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005479	decreased circulating triiodothyronine level	"less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0008965	increased basal metabolism	"increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0009395	persistence of primitive erythrocytes	"presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0009401	increased skeletal muscle fiber diameter	"increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ap3d1^mh-2J/Ap3d1^mh-2J Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0010225	abnormal quadriceps morphology	"any structural anomaly of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0010398	decreased liver glycogen level	"less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kif18a^tm1Zgwg/Kif18a^tm1Zgwg Genetic Background: either: 129-Kif18a^tm1Zgwg or (involves: 129 * C57BL/6J)
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0012107	enhanced exercise endurance	"improved performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0020470	shortened circadian behavior period	"decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]	Show Allelic Composition: Apc^Min/Apc⁺,Tgfbr1^tm1Bopa/Tgfbr1⁺ Genetic Background: B6.Cg-Tgfbr1^tm1Bopa Apc^Min
MP:0020523	decreased susceptibility to induced hypothermia	"smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]	Show Allelic Composition: Ncor1^tm1.1Ics/Ncor1^tm1.1Ics,Tg(ACTA1-cre)79Jme/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
MP:0020527	small thalamus	"decreased size of the thalamus" [MGI:smb]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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