Manteia

ENSMUSG00000029635

Mus musculus

Features

Gene ID:	ENSMUSG00000029635

Biological name :	Cdk8

Synonyms :	Cdk8 / Cyclin-dependent kinase 8 / Q8R3L8

Possible biological names infered from orthology :	P49336

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	G3
Gene start:	146231230
Gene end:	146302874

Corresponding Affymetrix probe sets:	10527508 (MoGene1.0st) 1460389_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031640 Ensembl peptide - ENSMUSP00000125668 Ensembl peptide - ENSMUSP00000125516 Ensembl peptide - ENSMUSP00000124525 Ensembl peptide - ENSMUSP00000124323 NCBI entrez gene - 264064 See in Manteia. MGI - MGI:1196224 RefSeq - XM_006504840 RefSeq - XM_006504839 RefSeq - XM_006504835 RefSeq - NM_153599 RefSeq - XM_006504836 RefSeq - XM_006504838 RefSeq Peptide - NP_705827 swissprot - Q8R3L8 swissprot - E9Q6E2 swissprot - E0CY29 swissprot - E0CYC4 swissprot - E0CZC3 Ensembl - ENSMUSG00000029635

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cdk19 / Q8BWD8 / Cyclin-dependent kinase 19 / Q9BWU1*	ENSMUSG00000038481	83

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007346	regulation of mitotic cell cycle	IBA
biological_process	GO:0016310	phosphorylation	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0016592	mediator complex	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

Generic Transcription Pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0009781	abnormal preimplantation embryo development	"an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj Genetic Background: 129S6/SvEvTac-Wwtr1^tm1Benj
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj Genetic Background: 129S6/SvEvTac-Wwtr1^tm1Benj
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cbx2^{tm1b(KOMP)Wtsi}/Cbx2⁺ Genetic Background: C57BL/6N-Cbx2^{tm1b(KOMP)Wtsi}/H
MP:0012111	failure of morula compaction	"inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [MGI:anna]	Show Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj Genetic Background: 129S6/SvEvTac-Wwtr1^tm1Benj

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024515	Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*	/ reaction
ENSMUSG00000024563	Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*	/ reaction
ENSMUSG00000028252	Ccnc / Q62447 / Cyclin-C / P24863*	/ complex
ENSMUSG00000032402	Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr