ENSMUSG00000018401


Mus musculus

Features
Gene ID: ENSMUSG00000018401
  
Biological name :Mtmr4
  
Synonyms : Mtmr4 / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA. / Q91XS1
  
Possible biological names infered from orthology : myotubularin related protein 4 / Q9NYA4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87592162
Gene end: 87616302
  
Corresponding Affymetrix probe sets: 10380087 (MoGene1.0st)   1418150_at (Mouse Genome 430 2.0 Array)   1418151_at (Mouse Genome 430 2.0 Array)   1459874_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119489
Ensembl peptide - ENSMUSP00000119446
Ensembl peptide - ENSMUSP00000119660
Ensembl peptide - ENSMUSP00000090478
Ensembl peptide - ENSMUSP00000099468
Ensembl peptide - ENSMUSP00000112902
NCBI entrez gene - 170749     See in Manteia.
MGI - MGI:2180699
RefSeq - XM_011248780
RefSeq - NM_001357901
RefSeq - NM_133215
RefSeq - XM_006532383
RefSeq - XM_006532384
RefSeq - XM_006532385
RefSeq Peptide - NP_001344830
RefSeq Peptide - NP_573478
swissprot - Q5ND05
swissprot - A7M7R1
swissprot - Q91XS1
swissprot - A7M7R0
Ensembl - ENSMUSG00000018401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTMR4ENSGALG00000001042Gallus gallus
 MTMR4ENSG00000108389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtmr3 / myotubularin related protein 3 / Q13615*ENSMUSG0000003435446
Mtmr2 / Q9Z2D1 / Myotubularin-related protein 2 / Q13614*ENSMUSG0000003191818
Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*ENSMUSG0000003652917
Mtmr6 / Q8VE11 / Myotubularin-related protein 6 / Q9Y217*ENSMUSG0000002198717
Mtm1 / Q9Z2C5 / X-linked myotubular myopathy gene 1 / Q13496* / myotubularin 1*ENSMUSG0000003133717
Mtmr1 / Q9Z2C4 / Myotubularin-related protein 1 / Q13613*ENSMUSG0000001521416
Sbf2 / SET binding factor 2 / Q86WG5*ENSMUSG0000003837116
Mtmr7 / Q9Z2C9 / Myotubularin-related protein 7 / Q9Y216*ENSMUSG0000003943116
Mtmr9 / Q9Z2D0 / Myotubularin-related protein 9 / Q96QG7*ENSMUSG0000003507814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR010569  Myotubularin-like phosphatase domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017455  Zinc finger, FYVE-related
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030590  Myotubularin-related protein 4
 IPR035997  MTMR4, PH-GRAM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex






 

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