ENSG00000108389


Homo sapiens

Features
Gene ID: ENSG00000108389
  
Biological name :MTMR4
  
Synonyms : MTMR4 / myotubularin related protein 4 / Q9NYA4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q22
Gene start: 58489529
Gene end: 58517905
  
Corresponding Affymetrix probe sets: 212277_at (Human Genome U133 Plus 2.0 Array)   214268_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464588
Ensembl peptide - ENSP00000464067
Ensembl peptide - ENSP00000464247
Ensembl peptide - ENSP00000325285
Ensembl peptide - ENSP00000462869
Ensembl peptide - ENSP00000463259
Ensembl peptide - ENSP00000463479
NCBI entrez gene - 9110     See in Manteia.
OMIM - 603559
RefSeq - XM_011525460
RefSeq - NM_004687
RefSeq - XM_005257784
RefSeq - XM_005257785
RefSeq - XM_005257786
RefSeq - XM_006722168
RefSeq Peptide - NP_004678
swissprot - Q9NYA4
swissprot - J3QKV8
swissprot - J3QLB9
swissprot - J3QR65
swissprot - J3QRJ2
swissprot - J3KT95
swissprot - J3QS98
Ensembl - ENSG00000108389
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTMR4ENSGALG00000001042Gallus gallus
 Mtmr4ENSMUSG00000018401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTMR3 / Q13615 / myotubularin related protein 3ENSG0000010033049
MTMR2 / Q13614 / myotubularin related protein 2ENSG0000008705318
MTM1 / Q13496 / myotubularin 1ENSG0000017110017
SBF1 / O95248 / SET binding factor 1ENSG0000010024117
MTMR6 / Q9Y217 / myotubularin related protein 6ENSG0000013950517
MTMR8 / Q96EF0 / myotubularin related protein 8ENSG0000010204317
SBF2 / Q86WG5 / SET binding factor 2ENSG0000013381216
MTMR1 / Q13613 / myotubularin related protein 1ENSG0000006360116
MTMR7 / Q9Y216 / myotubularin related protein 7ENSG0000000398716
MTMR9 / Q96QG7 / myotubularin related protein 9ENSG0000010464314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR010569  Myotubularin-like phosphatase domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017455  Zinc finger, FYVE-related
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030590  Myotubularin-related protein 4
 IPR035997  MTMR4, PH-GRAM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation IDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex






 

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