ENSG00000003987


Homo sapiens

Features
Gene ID: ENSG00000003987
  
Biological name :MTMR7
  
Synonyms : MTMR7 / myotubularin related protein 7 / Q9Y216
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p22
Gene start: 17298030
Gene end: 17413528
  
Corresponding Affymetrix probe sets: 215793_at (Human Genome U133 Plus 2.0 Array)   217292_at (Human Genome U133 Plus 2.0 Array)   243804_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429733
Ensembl peptide - ENSP00000431000
Ensembl peptide - ENSP00000180173
NCBI entrez gene - 9108     See in Manteia.
OMIM - 603562
RefSeq - NM_004686
RefSeq - XM_011544692
RefSeq - XM_017013956
RefSeq Peptide - NP_004677
swissprot - E5RK11
swissprot - Q9Y216
Ensembl - ENSG00000003987
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtmr7aENSDARG00000037101Danio rerio
 mtmr7bENSDARG00000070412Danio rerio
 ENSGALG00000036021Gallus gallus
 ENSGALG00000013641Gallus gallus
 Mtmr7ENSMUSG00000039431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTMR6 / Q9Y217 / myotubularin related protein 6ENSG0000013950555
MTMR8 / Q96EF0 / myotubularin related protein 8ENSG0000010204352
MTMR2 / Q13614 / myotubularin related protein 2ENSG0000008705332
MTM1 / Q13496 / myotubularin 1ENSG0000017110032
MTMR1 / Q13613 / myotubularin related protein 1ENSG0000006360131
MTMR3 / Q13615 / myotubularin related protein 3ENSG0000010033030
MTMR9 / Q96QG7 / myotubularin related protein 9ENSG0000010464330
MTMR4 / Q9NYA4 / myotubularin related protein 4ENSG0000010838929
SBF1 / O95248 / SET binding factor 1ENSG0000010024126
SBF2 / Q86WG5 / SET binding factor 2ENSG0000013381225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR010569  Myotubularin-like phosphatase domain
 IPR011993  PH-like domain superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030572  Myotubularin-related protein 7
 IPR036003  MTMR7, PH-GRAM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity TAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0052866 phosphatidylinositol phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the late endosome membrane
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104643 MTMR9 / Q96QG7 / myotubularin related protein 9  / reaction / complex






 

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