ENSG00000139505


Homo sapiens

Features
Gene ID: ENSG00000139505
  
Biological name :MTMR6
  
Synonyms : MTMR6 / myotubularin related protein 6 / Q9Y217
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.13
Gene start: 25246201
Gene end: 25288009
  
Corresponding Affymetrix probe sets: 214429_at (Human Genome U133 Plus 2.0 Array)   228789_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371221
NCBI entrez gene - 9107     See in Manteia.
OMIM - 603561
RefSeq - XM_017020845
RefSeq - NM_004685
RefSeq - XM_011535306
RefSeq - XM_011535307
RefSeq Peptide - NP_004676
swissprot - Q9Y217
Ensembl - ENSG00000139505
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtmr6ENSDARG00000016794Danio rerio
 MTMR6ENSGALG00000017112Gallus gallus
 Mtmr6ENSMUSG00000021987Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTMR7 / Q9Y216 / myotubularin related protein 7ENSG0000000398759
MTMR8 / Q96EF0 / myotubularin related protein 8ENSG0000010204357
MTMR2 / Q13614 / myotubularin related protein 2ENSG0000008705335
MTMR3 / Q13615 / myotubularin related protein 3ENSG0000010033034
MTMR1 / Q13613 / myotubularin related protein 1ENSG0000006360134
MTM1 / Q13496 / myotubularin 1ENSG0000017110033
MTMR4 / Q9NYA4 / myotubularin related protein 4ENSG0000010838933
MTMR9 / Q96QG7 / myotubularin related protein 9ENSG0000010464330
SBF1 / O95248 / SET binding factor 1ENSG0000010024127
SBF2 / Q86WG5 / SET binding factor 2ENSG0000013381225


Protein motifs (from Interpro)
Interpro ID Name
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR010569  Myotubularin-like phosphatase domain
 IPR011993  PH-like domain superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030581  Myotubularin-related protein 6
 IPR035998  MTMR6, PH-GRAM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation NAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IDA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IDA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity NAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015269 calcium-activated potassium channel activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity TAS
 molecular_functionGO:0052866 phosphatidylinositol phosphate phosphatase activity IEA
 molecular_functionGO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104643 MTMR9 / Q96QG7 / myotubularin related protein 9  / reaction / complex






 

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