ENSMUSG00000034354


Mus musculus

Features
Gene ID: ENSMUSG00000034354
  
Biological name :Mtmr3
  
Synonyms : Mtmr3 / myotubularin related protein 3
  
Possible biological names infered from orthology : Q13615
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 4480868
Gene end: 4594863
  
Corresponding Affymetrix probe sets: 10383867 (MoGene1.0st)   1427117_at (Mouse Genome 430 2.0 Array)   1434042_s_at (Mouse Genome 430 2.0 Array)   1443092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049079
Ensembl peptide - ENSMUSP00000116315
Ensembl peptide - ENSMUSP00000122422
Ensembl peptide - ENSMUSP00000137687
Ensembl peptide - ENSMUSP00000105569
NCBI entrez gene - 74302     See in Manteia.
MGI - MGI:1921552
RefSeq - XM_006514848
RefSeq - NM_028860
RefSeq - XM_006514845
RefSeq - XM_006514846
RefSeq - XM_006514847
RefSeq Peptide - NP_083136
swissprot - R4GML8
swissprot - M0QW74
swissprot - B1ATD5
swissprot - B1ATD4
Ensembl - ENSMUSG00000034354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtmr3ENSDARG00000098201Danio rerio
 mtmr3ENSDARG00000093364Danio rerio
 MTMR3ENSGALG00000008051Gallus gallus
 MTMR3ENSG00000100330Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtmr4 / Q91XS1 / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA. / Q9NYA4* / myotubularin related protein 4*ENSMUSG0000001840148
Mtmr2 / Q9Z2D1 / Myotubularin-related protein 2 / Q13614*ENSMUSG0000003191819
Mtm1 / Q9Z2C5 / X-linked myotubular myopathy gene 1 / Q13496* / myotubularin 1*ENSMUSG0000003133718
Mtmr7 / Q9Z2C9 / Myotubularin-related protein 7 / Q9Y216*ENSMUSG0000003943118
Mtmr6 / Q8VE11 / Myotubularin-related protein 6 / Q9Y217*ENSMUSG0000002198718
Sbf1 / Q6ZPE2 / SET binding factor 1 / O95248*ENSMUSG0000003652918
Mtmr1 / Q9Z2C4 / Myotubularin-related protein 1 / Q13613*ENSMUSG0000001521417
Sbf2 / SET binding factor 2 / Q86WG5*ENSMUSG0000003837116
Mtmr9 / Q9Z2D0 / Myotubularin-related protein 9 / Q96QG7*ENSMUSG0000003507814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR010569  Myotubularin-like phosphatase domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017455  Zinc finger, FYVE-related
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR035888  Myotubularin-related protein 3, PH-GRAM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation IEA
 biological_processGO:1904562 phosphatidylinositol 5-phosphate metabolic process IEA
 biological_processGO:2000785 regulation of autophagosome assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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