| MP:0000195 | hypocalcemia | "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay
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| MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
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| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0001674 | abnormal triploblastic development | "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0001695 | abnormal gastrulation | "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0001705 | abnormal proximal-distal axis patterning | "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0001706 | abnormal left-right axis patterning | "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
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| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
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| MP:0003425 | abnormal optic vesicle formation | "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0003886 | abnormal embryonic epiblast morphology | "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0004133 | heterotaxia | "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0004251 | failure of looping morphogenesis | "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0004252 | abnormal direction of looping morphogenesis | "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0005157 | holoprosencephaly | "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058] |
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0005163 | cyclopia | "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0005221 | abnormal rostral-caudal axis patterning | "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0006290 | proboscis | "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0008789 | abnormal olfactory epithelium morphology | "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Tfebtm1b(EUCOMM)Wtsi/Tfebtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tfebtm1b(EUCOMM)Wtsi/Bay
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0011192 | decreased embryonic epiblast cell proliferation | "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
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| MP:0011259 | abnormal cephalic neural fold morphology | "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
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| MP:0012138 | decreased forebrain size | "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0012157 | rostral body truncation | "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith] |
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0012685 | abnormal primitive streak elongation | "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna] |
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0012703 | decreased embryonic neuroepithelium thickness | "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
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| MP:0012706 | decreased embryonic neuroepithelial cell proliferation | "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna] |
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
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