ENSMUSG00000027210


Mus musculus

Features
Gene ID: ENSMUSG00000027210
  
Biological name :Meis2
  
Synonyms : Homeobox protein Meis2 / Meis2 / P97367
  
Possible biological names infered from orthology : Meis homeobox 2 / O14770
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 115863064
Gene end: 116065839
  
Corresponding Affymetrix probe sets: 10486041 (MoGene1.0st)   1417129_a_at (Mouse Genome 430 2.0 Array)   1440091_at (Mouse Genome 430 2.0 Array)   1447861_x_at (Mouse Genome 430 2.0 Array)   1457632_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106533
Ensembl peptide - ENSMUSP00000106531
Ensembl peptide - ENSMUSP00000106532
Ensembl peptide - ENSMUSP00000028639
Ensembl peptide - ENSMUSP00000073898
Ensembl peptide - ENSMUSP00000099597
NCBI entrez gene - 17536     See in Manteia.
MGI - MGI:108564
RefSeq - XM_017316117
RefSeq - NM_001136072
RefSeq - NM_001159567
RefSeq - NM_001159568
RefSeq - NM_001159569
RefSeq - NM_001159570
RefSeq - NM_010825
RefSeq - XM_011239336
RefSeq - XM_011239337
RefSeq - XM_017316101
RefSeq - XM_017316104
RefSeq - XM_017316107
RefSeq - XM_017316108
RefSeq - XM_017316109
RefSeq - XM_017316111
RefSeq - XM_017316112
RefSeq - XM_017316113
RefSeq - XM_017316114
RefSeq - XM_006498864
RefSeq - XM_006498865
RefSeq - XM_006498871
RefSeq Peptide - NP_001129544
RefSeq Peptide - NP_001153039
RefSeq Peptide - NP_001153040
RefSeq Peptide - NP_001153041
RefSeq Peptide - NP_001153042
RefSeq Peptide - NP_034955
swissprot - P97367
swissprot - Q3TYM2
swissprot - Q3UJ35
swissprot - Q6GU28
swissprot - B1AWK4
Ensembl - ENSMUSG00000027210
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 meis2aENSDARG00000098240Danio rerio
 MEIS2ENSGALG00000039118Gallus gallus
 MEIS2ENSG00000134138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Meis1 / Q60954 / Homeobox protein Meis1 / O00470* / Meis homeobox 1*ENSMUSG0000002016081
Meis3 / P97368 / Homeobox protein Meis3 / Q99687* / Meis homeobox 3*ENSMUSG0000004142053
Pknox2 / Q8BG99 / Homeobox protein PKNOX2 / Q96KN3* / PBX/knotted 1 homeobox 2*ENSMUSG0000003593432
O70477 / Pknox1 / Homeobox protein PKNOX1 / P55347* / PBX/knotted 1 homeobox 1*ENSMUSG0000000670530
Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*ENSMUSG0000004740713
Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*ENSMUSG0000006217510
Tgif2lx2 / TGFB-induced factor homeobox 2-like, X-linked 2 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001947
Tgif2lx1 / TGFB-induced factor homeobox 2-like, X-linked 1 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001337


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0110024 positive regulation of cardiac muscle myoblast proliferation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000039 abnormal otic capsule morphology "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0012250 absent heart valves "failure to form all of the membranous folds of the heart that prevent reflux of fluid" [MGI:anna]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0012747 abnormal cardiac neural crest cell morphology "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0013183 absent trigeminal ganglion "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [MGI:anna]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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