ENSMUSG00000006705


Mus musculus

Features
Gene ID: ENSMUSG00000006705
  
Biological name :Pknox1
  
Synonyms : Homeobox protein PKNOX1 / O70477 / Pknox1
  
Possible biological names infered from orthology : P55347 / PBX/knotted 1 homeobox 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 31564749
Gene end: 31607684
  
Corresponding Affymetrix probe sets: 10443817 (MoGene1.0st)   1421233_at (Mouse Genome 430 2.0 Array)   1437470_at (Mouse Genome 430 2.0 Array)   1450172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094966
Ensembl peptide - ENSMUSP00000134852
Ensembl peptide - ENSMUSP00000135804
NCBI entrez gene - 18771     See in Manteia.
MGI - MGI:1201409
RefSeq - XM_006523858
RefSeq - NM_016670
RefSeq - XM_006523856
RefSeq - XM_006523857
RefSeq - XM_006523854
RefSeq - XM_006523855
RefSeq Peptide - NP_057879
swissprot - O70477
Ensembl - ENSMUSG00000006705
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pknox1.1ENSDARG00000018765Danio rerio
 pknox1.2ENSDARG00000036542Danio rerio
 PKNOX1ENSGALG00000016191Gallus gallus
 P55347ENSG00000160199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pknox2 / Q8BG99 / Homeobox protein PKNOX2 / Q96KN3* / PBX/knotted 1 homeobox 2*ENSMUSG0000003593463
Meis1 / Q60954 / Homeobox protein Meis1 / O00470* / Meis homeobox 1*ENSMUSG0000002016033
Meis2 / P97367 / Homeobox protein Meis2 / O14770* / Meis homeobox 2*ENSMUSG0000002721033
Meis3 / P97368 / Homeobox protein Meis3 / Q99687* / Meis homeobox 3*ENSMUSG0000004142030
Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*ENSMUSG0000004740712
Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*ENSMUSG0000006217511
Tgif2lx1 / TGFB-induced factor homeobox 2-like, X-linked 1 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001338
Tgif2lx2 / TGFB-induced factor homeobox 2-like, X-linked 2 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001948


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IGI
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6tm1.2Xzh/Pax6tm1.2Xzh
Genetic Background: B6.129S6-Pax6tm1.2Xzh

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprdtm1Yiw/Ptprd+,Ptprstm1Mtr/Ptprstm1Mtr
Genetic Background: B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004196 abnormal prenatal growth/weight/body size "limited or accelerated growth or development apparent before birth" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syngap1tm2Geno/Syngap1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pknox1tm1.2Xzh/Pknox1tm1.2Xzh
Genetic Background: involves: C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: B6.Cg-Pknox1tm1Fbla

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tbx1tm1Bld/Tbx1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: B6.Cg-Pknox1tm1Fbla

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
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Allelic Composition: Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: B6.Cg-Pknox1tm1Fbla

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018973 Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*  / complex
 ENSMUSG00000052534 Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex






 

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