ENSG00000160199


Homo sapiens

Features
Gene ID: ENSG00000160199
  
Biological name :PKNOX1
  
Synonyms : P55347 / PBX/knotted 1 homeobox 1 / PKNOX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 42974510
Gene end: 43033931
  
Corresponding Affymetrix probe sets: 204195_s_at (Human Genome U133 Plus 2.0 Array)   204196_x_at (Human Genome U133 Plus 2.0 Array)   216004_s_at (Human Genome U133 Plus 2.0 Array)   221883_at (Human Genome U133 Plus 2.0 Array)   54051_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453486
Ensembl peptide - ENSP00000291547
Ensembl peptide - ENSP00000402243
NCBI entrez gene - 5316     See in Manteia.
OMIM - 602100
RefSeq - NM_001286258
RefSeq - NM_001320694
RefSeq - NM_004571
RefSeq Peptide - NP_001307623
RefSeq Peptide - NP_001273187
RefSeq Peptide - NP_004562
swissprot - P55347
swissprot - E7EPN6
swissprot - Q96I87
swissprot - H0YM69
Ensembl - ENSG00000160199
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pknox1.1ENSDARG00000018765Danio rerio
 pknox1.2ENSDARG00000036542Danio rerio
 PKNOX1ENSGALG00000016191Gallus gallus
 O70477ENSMUSG00000006705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKNOX2 / Q96KN3 / PBX/knotted 1 homeobox 2ENSG0000016549563
MEIS2 / O14770 / Meis homeobox 2ENSG0000013413833
MEIS1 / O00470 / Meis homeobox 1ENSG0000014399533
MEIS3 / Q99687 / Meis homeobox 3ENSG0000010541930
TGIF1 / Q15583 / TGFB induced factor homeobox 1ENSG0000017742614
Q8IUE1 / TGIF2LX / TGFB induced factor homeobox 2 like, X-linkedENSG0000015377911
TGIF2 / Q9GZN2 / TGFB induced factor homeobox 2ENSG0000011870711
Q8IUE0 / TGIF2LY / TGFB induced factor homeobox 2 like, Y-linkedENSG000001766799


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol HDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120094 HOXB1 / P14653 / homeobox B1  / complex
 ENSG00000185630 PBX1 / P40424 / PBX homeobox 1  / complex






 

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