ENSDARG00000018765


Danio rerio

Features
Gene ID: ENSDARG00000018765
  
Biological name :pknox1.1
  
Synonyms : pbx/knotted 1 homeobox 1.1 / pknox1.1
  
Possible biological names infered from orthology : Homeobox protein PKNOX1 / O70477 / P55347 / PBX/knotted 1 homeobox 1 / PKNOX1
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 19529951
Gene end: 19550058
  
Corresponding Affymetrix probe sets: Dr.7485.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000111569
NCBI entrez gene - 798151     See in Manteia.
swissprot - Q90VY7
ZFIN ID - ZDB-GENE-020122-5
Ensembl - ENSDARG00000018765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKNOX1ENSGALG00000016191Gallus gallus
 P55347ENSG00000160199Homo sapiens
 O70477ENSMUSG00000006705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pknox1.2 / pbx/knotted 1 homeobox 1.2 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000003654269
pknox2 / pbx/knotted 1 homeobox 2 / Q8BG99* / Q96KN3* / Homeobox protein PKNOX2 *ENSDARG0000005534956
meis2a / Meis homeobox 2a / MEIS2* / P97367* / O14770* / Meis homeobox 2* / Homeobox protein Meis2 *ENSDARG0000009824032
meis1b / Meis homeobox 1 b / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000001207831
meis3 / myeloid ecotropic viral integration site 3 / P97368* / Q99687* / Meis homeobox 3* / Homeobox protein Meis3 *ENSDARG0000000279531
meis2a / meis2b / Meis homeobox 2bENSDARG0000007784031
meis1a / Meis homeobox 1 a / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000000293730
tgif1 / TGFB-induced factor homeobox 1 / P70284* / Q15583*ENSDARG0000005933711
FO834857.1 / TGIF2* / Q9GZN2* / TGFB induced factor homeobox 2*ENSDARG0000011289510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0014033 neural crest cell differentiation IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0031060 regulation of histone methylation IGI
 biological_processGO:0031061 negative regulation of histone methylation IGI
 biological_processGO:0035066 positive regulation of histone acetylation IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain apoptotic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus mislocalised , abnormal
Show

 ZFA:0001064 rhombomere rhombomere neuron organization quality , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type mandibular arch skeleton , abnormal
whole organism viability , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin atrophied , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased size , abnormal
ethmoid cartilage deformed , abnormal
Show

 ZFA:0001507 trabecula cranii trabecula cranii decreased size , abnormal
trabecula cranii deformed , abnormal
Show

 ZFA:0009091 melanocyte melanocyte spatial pattern , abnormal
Show

 ZFA:0009191 CNS interneuron CNS interneuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr