ENSDARG00000012078


Danio rerio

Features
Gene ID: ENSDARG00000012078
  
Biological name :meis1b
  
Synonyms : meis1b / Meis homeobox 1 b
  
Possible biological names infered from orthology : Homeobox protein Meis1 / MEIS1 / Meis homeobox 1 / O00470 / Q60954
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 5490551
Gene end: 5569562
  
Corresponding Affymetrix probe sets: Dr.3336.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000093352
Ensembl peptide - ENSDARP00000152955
NCBI entrez gene - 170446     See in Manteia.
swissprot - Q90XH2
ZFIN ID - ZDB-GENE-020122-1
Ensembl - ENSDARG00000012078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEIS1ENSGALG00000041626Gallus gallus
 MEIS1ENSG00000143995Homo sapiens
 Meis1ENSMUSG00000020160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
meis2a / Meis homeobox 2a / MEIS2* / P97367* / O14770* / Meis homeobox 2* / Homeobox protein Meis2 *ENSDARG0000009824081
meis2a / meis2b / Meis homeobox 2bENSDARG0000007784081
meis1a / Meis homeobox 1 a / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000000293776
meis3 / myeloid ecotropic viral integration site 3 / P97368* / Q99687* / Meis homeobox 3* / Homeobox protein Meis3 *ENSDARG0000000279561
pknox2 / pbx/knotted 1 homeobox 2 / Q8BG99* / Q96KN3* / Homeobox protein PKNOX2 *ENSDARG0000005534937
pknox1.1 / pbx/knotted 1 homeobox 1.1 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000001876535
pknox1.2 / pbx/knotted 1 homeobox 1.2 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000003654233
tgif1 / TGFB-induced factor homeobox 1 / P70284* / Q15583*ENSDARG0000005933712
FO834857.1 / TGIF2* / Q9GZN2* / TGFB induced factor homeobox 2*ENSDARG000001128959


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001885 endothelial cell development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0035476 angioblast cell migration IMP
 biological_processGO:0035907 dorsal aorta development IMP
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0050821 protein stabilization IPI
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060319 primitive erythrocyte differentiation IMP
 biological_processGO:0060841 venous blood vessel development IMP
 biological_processGO:0072554 blood vessel lumenization IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta fused with posterior cardinal vein , abnormal
dorsal aorta morphology , abnormal
dorsal aorta hematopoietic stem cell amount , ameliorated
Show

 ZFA:0000029 hindbrain hindbrain morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000094 blood island blood island macrophage decreased amount , abnormal
blood island neutrophil decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart inverted , abnormal
Show

 ZFA:0000152 retina retina morphology , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
optic tectum grey matter decreased mass , abnormal
Show

 ZFA:0001202 optic cup optic cup wholly ventralized , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage fused with palatoquadrate cartilage , abnormal
Meckels cartilage fused with hyosymplectic cartilage , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage flattened , abnormal
palatoquadrate cartilage rotated , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage fused with ceratobranchial cartilage , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage mislocalised , abnormal
cranial cartilage morphology , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage fused with ceratobranchial cartilage , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte absent , abnormal
Show

 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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