ENSMUSG00000020160


Mus musculus

Features
Gene ID: ENSMUSG00000020160
  
Biological name :Meis1
  
Synonyms : Homeobox protein Meis1 / Meis1 / Q60954
  
Possible biological names infered from orthology : Meis homeobox 1 / O00470
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.1
Gene start: 18879817
Gene end: 19018985
  
Corresponding Affymetrix probe sets: 10384504 (MoGene1.0st)   1443260_at (Mouse Genome 430 2.0 Array)   1450992_a_at (Mouse Genome 430 2.0 Array)   1459423_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099942
Ensembl peptide - ENSMUSP00000139074
Ensembl peptide - ENSMUSP00000069277
Ensembl peptide - ENSMUSP00000139219
Ensembl peptide - ENSMUSP00000134969
Ensembl peptide - ENSMUSP00000135726
NCBI entrez gene - 17268     See in Manteia.
MGI - MGI:104717
RefSeq - XM_017314312
RefSeq - XM_006514559
RefSeq - NM_001193271
RefSeq - NM_010789
RefSeq - XM_017314313
RefSeq Peptide - NP_034919
RefSeq Peptide - NP_001180200
swissprot - V9GXB5
swissprot - Q60954
swissprot - H3BLB6
swissprot - A0A0A0MQB8
Ensembl - ENSMUSG00000020160
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 meis1aENSDARG00000002937Danio rerio
 meis1bENSDARG00000012078Danio rerio
 MEIS1ENSGALG00000041626Gallus gallus
 MEIS1ENSG00000143995Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Meis2 / P97367 / Homeobox protein Meis2 / O14770* / Meis homeobox 2*ENSMUSG0000002721083
Meis3 / P97368 / Homeobox protein Meis3 / Q99687* / Meis homeobox 3*ENSMUSG0000004142054
Pknox2 / Q8BG99 / Homeobox protein PKNOX2 / Q96KN3* / PBX/knotted 1 homeobox 2*ENSMUSG0000003593431
O70477 / Pknox1 / Homeobox protein PKNOX1 / P55347* / PBX/knotted 1 homeobox 1*ENSMUSG0000000670531
Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*ENSMUSG0000004740714
Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*ENSMUSG0000006217510
Tgif2lx1 / TGFB-induced factor homeobox 2-like, X-linked 1 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001338
Tgif2lx2 / TGFB-induced factor homeobox 2-like, X-linked 2 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG000001001948


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IC
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IGI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Meis1tm3.1(cre/ERT2)Mtor/Meis1tm3.1(cre/ERT2)Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: Not Specified

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

Allelic Composition: Meis1tm2.1Mtor/Meis1tm2.1Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Meis1tm3.1(cre/ERT2)Mtor/Meis1tm3.1(cre/ERT2)Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: Not Specified

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+,Tg(Tek-cre)2352Rwng/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+,Tg(Tek-cre)2352Rwng/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0003714 absence of platelets "lack of non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

Allelic Composition: Meis1tm2.1Mtor/Meis1tm2.1Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Meis1tm3.1(cre/ERT2)Mtor/Meis1tm3.1(cre/ERT2)Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: Not Specified

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+,Tg(Tek-cre)2352Rwng/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0008253 absent megakaryocytes "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

Allelic Composition: Meis1tm2.1Mtor/Meis1tm2.1Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Meis1tm2.1Mtor/Meis1tm2.1Mtor
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meis1tm2Ngc/Meis1tm2Ngc,Tg(Tal1-cre/ERT)42-056Jrg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0020327 abnormal capillary branching pattern "any changes in the placement, morphology or number of divisions of the capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMID:14713950]
Show

Allelic Composition: Meis1tm1Ngc/Meis1tm1Ngc
Genetic Background: involves: 129 * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052534 Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*  / complex
 ENSMUSG00000018973 Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*  / complex






 

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