Manteia

ENSMUSG00000018973

Mus musculus

Features

Gene ID:	ENSMUSG00000018973

Biological name :	Hoxb1

Synonyms :	Homeobox protein Hox-B1 / Hoxb1 / P17919

Possible biological names infered from orthology :	homeobox B1 / P14653

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	96365752
Gene end:	96368256

Corresponding Affymetrix probe sets:	10380665 (MoGene1.0st) 1453501_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000019117 NCBI entrez gene - 15407 See in Manteia. MGI - MGI:96182 RefSeq - NM_008266 RefSeq - XM_006532280 RefSeq Peptide - NP_032292 swissprot - P17919 Ensembl - ENSMUSG00000018973

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HOXB1	ENSG00000120094	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hoxa1 / homeobox A1 / P49639*	ENSMUSG00000029844	48
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*	ENSMUSG00000042448	36
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*	ENSMUSG00000048763	28
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*	ENSMUSG00000079560	27
Hoxd3 / P09027 / homeobox D3 / P31249*	ENSMUSG00000079277	26
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*	ENSMUSG00000075588	24
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*	ENSMUSG00000014704	23
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*	ENSMUSG00000029644	22
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*	ENSMUSG00000053129	20
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*	ENSMUSG00000035946	20
Gm28308	ENSMUSG00000101298	1

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0009653	anatomical structure morphogenesis	IGI
biological_process	GO:0009952	anterior/posterior pattern specification	IGI
biological_process	GO:0021546	rhombomere development	IDA
biological_process	GO:0021570	rhombomere 4 development	IGI
biological_process	GO:0021571	rhombomere 5 development	IGI
biological_process	GO:0021612	facial nerve structural organization	IMP
biological_process	GO:0021754	facial nucleus development	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	IGI
biological_process	GO:0048704	embryonic skeletal system morphogenesis	IGI
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0019904	protein domain specific binding	ISO
molecular_function	GO:0043565	sequence-specific DNA binding	IGI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1^tm1(cre)Og Genetic Background: involves: 129S/SvEv
MP:0000680	absent parathyroid glands	"missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000705	athymia	"absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000843	absent facial nuclei	"missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Pdgfra^tm1Sor/Pdgfra^tm1Sor Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J) Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0000909	abnormal facial motor nucleus morphology	"malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Wisp3^tm1(cre)Mawa/Wisp3^tm1(cre)Mawa Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000910	small facial motor nucleus	"reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science:ISBN 0-8385-8034-3, J:56847]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000933	abnormal rhombomere morphology	"malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000939	reduced motor neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm7Mrc,Tfap2a^tm1(cre)Moon/Tfap2a⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000966	reduced sensory neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Grin1^tm2Stl/Grin1^tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)T29-1Stl/0,Tg(tetO-Grin1/GFP)1Jzt/0 Genetic Background: involves: C57BL/6 * CBA
MP:0001071	abnormal facial nerve morphology	"malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm7Mrc,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: Not Specified Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0001490	abnormal vibrissae reflex	"animals do not change position in response to stimulation of the whiskers" [J:17194]	Show Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0001961	abnormal reflex	"anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm9Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001993	abnormal blinking		Show Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prdx1^tm1Rave/Prdx1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Hoxb1^tm7Mrc/Hoxb1^tm7Mrc Genetic Background: Not Specified Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
MP:0002863	improved righting response	"faster ability or less amount of time needed to recover from supine position" [J:86936]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0002950	abnormal neural crest cell migration	"defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003312	abnormal locomotor coordination	"reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1^tm1(cre)Og Genetic Background: involves: 129S/SvEv
MP:0003998	decreased thermal nociceptive threshold	"a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0004204	absent stapes	"absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004235	abnormal masseter muscle morphology	"any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004239	abnormal temporalis muscle morphology	"any structural anomaly of the superior-most masticatory muscle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004263	abnormal limb posture	"atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0004561	absent facial nerve	"absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Pdgfra^tm1Sor/Pdgfra^tm1Sor Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)
MP:0004748	increased susceptibility to age-related hearing loss	"greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0005156	bradykinesia	"decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0005498	hyporesponsive to tactile stimuli	"reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0006031	abnormal branchial pouch morphology	"malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006282	abnormal posterior horn morphology	"any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0006334	abnormal susceptibility to hearing loss	"anomaly in the sensitivity to loss of hearing related to age or environmental factors " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0006345	absent second branchial arch	"missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008372	small malleus	"reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺,Pbx3^tm1Og/Pbx3^tm1Og Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs Genetic Background: involves: C57BL/6 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0012261	increased hindbrain apoptosis	"increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012490	abnormal cochlear VIII nucleus morphology	"any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]	Show Allelic Composition: Wisp3^tm1(cre)Mawa/Wisp3^tm1(cre)Mawa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Hoxb1^tm1Mist/Hoxb1^tm1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1 Allelic Composition: Hoxb1^tm1.1Mist/Hoxb1^tm1.1Mist,Tg(Hoxb1-cre)r4Mist/0,Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
MP:0012524	abnormal lower lip morphology	"any structural anomaly of the muscular fold bounding the opening of the mouth inferiorly" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0012746	abnormal neural crest cell delamination	"any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [MGI:anna]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0012796	abnormal rhombomere 4 morphology	"any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005511]	Show Allelic Composition: Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb1^tm2Brd/Hoxb1^tm2Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0012799	absent rhombomere 4	"absence of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012803	absent rhombomere 5	"absence of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013224	absent second pharyngeal pouch	"absence of the second branchial pouch, normally located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils" [PMID:20144910]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013225	abnormal third pharyngeal pouch morphology	"any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030040	absent facial muscle	"absence of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression; facial muscles are derived from the second branchial/pharyngeal arch" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030067	narrow face	"a reduction in the width of the upper and lower face" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0030106	small incus	"reduced size of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [https://radiopaedia.org/articles/incus]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030141	facial paralysis	"complete loss of power of voluntary movement in muscles of the face through injury or disease of it or its nerve supply; facial muscles are innervated by the facial nerve (i.e., the seventh cranial nerve)" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
MP:0030142	facial muscle degeneration	"pathological deterioration of facial muscle tissue, often accompanied by loss of function" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0030146	abnormal digastric posterior belly morphology	"any structural anomaly of the longer, posterior belly of the digastric muscle arising from the mastoid notch which is on the inferior surface of the skull, medial to the mastoid process of the temporal bone; the posterior belly is supplied by the digastric branch of facial nerve" []	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030149	abnormal stylohyoid muscle morphology	"any structural anomaly of the slender suprahyoid muscle lying anterior and superior of the posterior belly of the digastric muscle; it arises from the styloid process of the temporal bone and inserts into the body of the hyoid bone; it is perforated, near its insertion, by the intermediate tendon of the digastric muscle; the stylohyoid elevates and retracts the hyoid bone, elongating the floor of the mouth during swallowing" []	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030151	abnormal buccinator muscle morphology	"any structural anomaly of the thin quadrilateral muscle occupying the interval between the maxilla and the mandible at the side of the face that forms the anterior part of the cheek or the lateral wall of the oral cavity; it compresses the cheeks against the teeth and is used in acts such as blowing; it is an assistant muscle of mastication and in neonates it is used to suckle" []	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0030152	abnormal depressor anguli oris muscle morphology	"any structural anomaly of the facial muscle that originates from the mandible and inserts into the angle of the mouth; it is innervated by the marginal mandibular branch of the facial nerve and receives its blood supply from the facial artery; the muscle depresses the corners of the mouth which is associated with frowning" []	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0030174	absent orbicularis oculi muscle	"absence of the ring-like (sphincter) facial muscle composed of skeletal muscle fibers and arranged in concentric bands around the upper and lower eyelids; its primary function is to close the eyelids" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030177	absent levator labii superioris muscle	"missing the facial muscle that is shaped like a broad, flat sheet, the origin of which extends from the side of the nose to the zygomatic bone; its main function is to elevate the upper lip" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030184	abnormal zygomaticus muscle morphology	"any structural anomaly of the zygomaticus major and/or minor facial muscles that originate from the body of the zygoma and pass downwards to insert into the corner of the mouth and lateral aspect of the upper lip, respectively; these muscles receive their nerve supply on their deep surface from the zygomatic and buccal branches of the facial nerve and lift the corners of the mouth" [ISBN:978-3-642-21836-1, MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0030207	absent zygomaticus muscle	"absence of the zygomaticus major and/or minor facial muscles that originate from the body of the zygoma and pass downwards to insert into the corner of the mouth and lateral aspect of the upper lip, respectively" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030430	absent levator nasolabialis muscle	"missing the flat, thin muscle that lies beneath the skin on the lateral surface of the maxillary bone; it arises from the maxillary bone, over the dorsum of the nose, and runs cranioventrally to insert partly on the wing of the nostril and partly into the lateral part of the upper lip; it acts to dilate the nostrils and elevate and retract the upper lip" [MGI:anna]	Show Allelic Composition: Hoxb1^tm1Mrc/Hoxb1^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Hoxb1^tm2Mrc/Hoxb1^tm2Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000006705	O70477 / Pknox1 / Homeobox protein PKNOX1 / P55347* / PBX/knotted 1 homeobox 1*	/ complex
ENSMUSG00000052534	Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*	/ complex
ENSMUSG00000020160	Meis1 / Q60954 / Homeobox protein Meis1 / O00470* / Meis homeobox 1*	/ complex
ENSMUSG00000100210	P84228 / Hist1h3f / Histone H3.2	/ complex
ENSMUSG00000099517	P68433 / Hist1h3g / Histone H3.1	/ complex
ENSMUSG00000060743	H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*	/ complex
ENSMUSG00000060981	P62806 / Hist1h4h / Histone H4	/ complex

1 s.

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