ENSMUSG00000029644


Mus musculus

Features
Gene ID: ENSMUSG00000029644
  
Biological name :Pdx1
  
Synonyms : P52946 / Pancreas/duodenum homeobox protein 1 / Pdx1
  
Possible biological names infered from orthology : P52945 / pancreatic and duodenal homeobox 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G3
Gene start: 147269959
Gene end: 147275848
  
Corresponding Affymetrix probe sets: 10527565 (MoGene1.0st)   1422173_at (Mouse Genome 430 2.0 Array)   1422174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082729
NCBI entrez gene - 18609     See in Manteia.
MGI - MGI:102851
RefSeq - NM_008814
RefSeq Peptide - NP_032840
swissprot - P52946
Ensembl - ENSMUSG00000029644
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdx1ENSDARG00000002779Danio rerio
 PDX1ENSGALG00000038454Gallus gallus
 PDX1ENSG00000139515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*ENSMUSG0000007956031
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*ENSMUSG0000001470429
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*ENSMUSG0000003594629
Hoxd3 / P09027 / homeobox D3 / P31249*ENSMUSG0000007927729
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*ENSMUSG0000004876328
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*ENSMUSG0000007558828
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*ENSMUSG0000005312925
Hoxa1 / homeobox A1 / P49639*ENSMUSG0000002984423
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*ENSMUSG0000001897323
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*ENSMUSG0000004244821
Gm28308ENSMUSG000001012982


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0006006 glucose metabolic process IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010040 response to iron(II) ion IEA
 biological_processGO:0010157 response to chlorate IEA
 biological_processGO:0010260 animal organ senescence IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0033273 response to vitamin IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051594 detection of glucose IEA
 biological_processGO:0060290 transdifferentiation IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:2000675 negative regulation of type B pancreatic cell apoptotic process IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1Egs/Pdx1+,Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox17tm1Jaw/Sox17tm1Jaw,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000497 abnormal small intestine placement "different location or arrangement of the small intestinal tract" [J:40203]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Sox10gt/Sox10+
Genetic Background: HYIII/LeJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox10gt/Sox10+
Genetic Background: HYIII/LeJ

Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sox10gt/Sox10+
Genetic Background: HYIII/LeJ

Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cacng2stg-wag/Cacng2stg-wag
Genetic Background: B6.MRL-Cacng2stg-wag/J

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm4Cvw/Pdx1tm4Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Pdx1tm4Cvw/Pdx1tm4Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002710 increased glucagon secretion "greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm3Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm1.1Stof/Pdx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pdx1tm1Egs/Pdx1+,Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0003337 acinar hyperplasia "increased numbers of cells in the portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003655 absent pancreas "absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:20779]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm3Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Neurog3)8Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004141 abnormal enteroendocrine cell morphology "malformation of the somatostatin and gastrin secreting epithelial cells present throughout the epithelium of the digestive tract" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm3Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1Cvw/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacng2stg-wag/Cacng2stg-wag
Genetic Background: B6.MRL-Cacng2stg-wag/J

Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Neurog3tm1.1(cre/ERT)Ggu/Neurog3+,Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005218 abnormal pancreatic delta cell morphology "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox10gt/Sox10+
Genetic Background: HYIII/LeJ

Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm1Macd/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Pdx1tm3Cvw/Pdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm1.1Stof/Pdx1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm3Cvw/Pdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Pdx1tm2Cvw/Pdx1+,Slc2a4tm1Mch/Slc2a4+
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009109 decreased pancreas weight "reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Pdx1tm1Ted/Pdx1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pdx1tm1.1Stof/Pdx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009154 pancreatic acinar hypoplasia "underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009169 pancreatic islet hypoplasia "underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009170 abnormal pancreatic islet size "anomaly in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,EGFP)956.6Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pdx1tm3Cvw/Pdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009180 increased pancreatic delta cell number "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

 MP:0009184 abnormal PP cell morphology "any structural anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009185 increased PP cell number "increased number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
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Allelic Composition: Pdx1tm3Cvw/Pdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

 MP:0009189 abnormal pancreatic epsilon cell morphology "any structural anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,Pbx1tm1Mlc/Pbx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Pdx1tm1Heed/Pdx1tm1Heed,Tg(Ins2-cre)1Heed/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pdx1tm3Cvw/Pdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0009861 abnormal pyloric sphincter morphology "any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010785 abnormal stomach pyloric region morphology "any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0010803 abnormal stomach enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: either: 129P2/OlaHsd-Itgb1tm2Son or (involves: 129P2/OlaHsd * FVB)

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm2Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Pdx1tm2Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * FVB/N

Allelic Composition: Pdx1tm3Cvw/Pdx1tm3Cvw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

 MP:0011911 abnormal pancreatic endocrine progenitor cell physiology "any functional anomaly of a multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells" [CL:0002351]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012520 absent Brunner s glands "absence of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes" [MGI:anna]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm1Cvw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0014109 increased pancreatic alpha cell proliferation "increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [MGI:Anna]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

 MP:0014116 abnormal pancreatic beta cell apoptosis "change in the timing or the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0014117 increased pancreatic beta cell apoptosis "increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014125 decreased amylin secretion "reduction in the production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
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Allelic Composition: Pdx1tm2Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0030588 decreased pancreatic alpha cell mass "reduced total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: Pdx1tm1.1Stof/Pdx1tm1.1Stof
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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