ENSDARG00000002779


Danio rerio

Features
Gene ID: ENSDARG00000002779
  
Biological name :pdx1
  
Synonyms : pancreatic and duodenal homeobox 1 / pdx1
  
Possible biological names infered from orthology : P52945 / P52946 / Pancreas/duodenum homeobox protein 1
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 21684189
Gene end: 21686706
  
Corresponding Affymetrix probe sets: Dr.583.1.S1_at (Zebrafish Array)   NM_131443_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017531
NCBI entrez gene - 30721     See in Manteia.
RefSeq - NM_131443
RefSeq Peptide - NP_571518
swissprot - F1RBA3
ZFIN ID - ZDB-GENE-990415-122
Ensembl - ENSDARG00000002779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDX1ENSGALG00000038454Gallus gallus
 PDX1ENSG00000139515Homo sapiens
 Pdx1ENSMUSG00000029644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hoxb2a / homeobox B2a / HOXA2* / O43364* / P31245* / homeobox A2* / Homeobox protein Hox-A2 *ENSDARG0000000017527
O42368 / hoxb3a / homeobox B3a / HOXB3* / P09026* / P14651* / homeobox B3* / Homeobox protein Hox-B3 *ENSDARG0000002926327
hoxa2b / homeobox A2b / HOXA2* / O43364* / P31245* / homeobox A2* / Homeobox protein Hox-A2 *ENSDARG0000002303127
hoxd3a / O42370 / homeobox D3a / HOXD3* / P31249* / P09027* / homeobox D3*ENSDARG0000005928026
Q9PWL5 / hoxa3a / hoxa4a / Q8AWZ2 / homeobox A3a / HOXA3* / P02831* / O43365* / homeobox A3* / Homeobox protein Hox-A3 *ENSDARG0000010386225
gsx2 / GS homeobox 2 / P31316* / Q9BZM3*ENSDARG0000004332225
hoxb1a / homeobox B1aENSDARG0000000817423
gsx1 / GS homeobox 1 / P31315* / Q9H4S2*ENSDARG0000003573523
hoxb1b / homeobox B1bENSDARG0000005403322
hoxa1a / Q98SI1 / homeobox A1a / HOXA1* / P49639* / homeobox A1*ENSDARG0000010430722
hoxc3a / homeobox C3aENSDARG0000007033922
hoxc1a / Q98SH9 / homeobox C1a / HOXD1* / Q01822* / Q9GZZ0* / homeobox D1* / Homeobox protein Hox-D1 *ENSDARG0000007033720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000151 pronephros pronephros renal filtration decreased occurrence , abnormal
Show

 ZFA:0000339 digestive system digestive system positional polarity , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased weight , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas hypoplastic , abnormal
exocrine pancreas polarity , abnormal
exocrine pancreas disorganized , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas decreased size , abnormal
endocrine pancreas decreased functionality , abnormal
endocrine pancreas hypoplastic , abnormal
endocrine pancreas has fewer parts of type endodermal cell , abnormal
endocrine pancreas decreased distribution , abnormal
endocrine pancreas decreased amount , abnormal
Show

 ZFA:0001370 posterior pancreatic bud posterior pancreatic bud decreased size , abnormal
posterior pancreatic bud elongated , abnormal
posterior pancreatic bud cellular motility , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased width , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule decreased length , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte glomerular visceral epithelial cell development decreased process quality , abnormal
pronephric podocyte podocyte foot malformed , abnormal
pronephric podocyte podocyte foot dystrophic , abnormal
Show

 ZFA:0005739 pancreatic acinar cell pancreatic acinar cell absent , abnormal
Show

 ZFA:0005756 secondary islet secondary islet absent , abnormal
secondary islet decreased amount , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell absent , abnormal
pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased area , abnormal
Show

 ZFA:0009277 acinar cell acinar cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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