Manteia - Molecule gene

ENSMUSG00000029844

Mus musculus

Features

Gene ID:	ENSMUSG00000029844

Biological name :	Hoxa1

Synonyms :	homeobox A1 / Hoxa1

Possible biological names infered from orthology :	P49639

Species:	Mus musculus

Chr. number:	6
Strand:	-1
Band:	B3
Gene start:	52155590
Gene end:	52158317

Corresponding Affymetrix probe sets:	10544746 (MoGene1.0st) 1420565_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000000964 Ensembl peptide - ENSMUSP00000113724 NCBI entrez gene - 15394 See in Manteia. MGI - MGI:96170 RefSeq - NM_010449 RefSeq - NM_001311118 RefSeq - XM_006505607 RefSeq Peptide - NP_001298047 RefSeq Peptide - NP_034579 swissprot - D3Z4E1 swissprot - B9EHK7 Ensembl - ENSMUSG00000029844

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hoxa1a	ENSDARG00000104307	Danio rerio
HOXA1	ENSGALG00000028095	Gallus gallus
HOXA1	ENSG00000105991	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*	ENSMUSG00000018973	43
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*	ENSMUSG00000042448	34
Hoxd3 / P09027 / homeobox D3 / P31249*	ENSMUSG00000079277	24
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*	ENSMUSG00000048763	23
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*	ENSMUSG00000079560	22
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*	ENSMUSG00000075588	21
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*	ENSMUSG00000014704	21
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*	ENSMUSG00000029644	20
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*	ENSMUSG00000053129	16
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*	ENSMUSG00000035946	16
Gm28308	ENSMUSG00000101298	1

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007605	sensory perception of sound	IEA
biological_process	GO:0007634	optokinetic behavior	IEA
biological_process	GO:0009653	anatomical structure morphogenesis	IEA
biological_process	GO:0021599	abducens nerve formation	IEA
biological_process	GO:0042473	outer ear morphogenesis	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048702	embryonic neurocranium morphogenesis	IEA
biological_process	GO:0048839	inner ear development	IEA
biological_process	GO:0048844	artery morphogenesis	IEA
biological_process	GO:0050795	regulation of behavior	IEA
biological_process	GO:0050890	cognition	IEA
biological_process	GO:0050905	neuromuscular process	IEA
biological_process	GO:0060840	artery development	IEA
biological_process	GO:0060876	semicircular canal formation	IEA
biological_process	GO:0090102	cochlea development	IEA
biological_process	GO:0090103	cochlea morphogenesis	IEA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitx2^tm1Kki/Pitx2^tm1Kki Genetic Background: involves: 129P2/OlaHsd * C57BL
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000030	abnormal tympanic ring morphology	"malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0000033	absent cochlear duct	"missing spiral tube within the cochlea; contains the neuroepithelial receptor organ for hearing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000036	absent semicircular canals	"missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000039	abnormal otic capsule morphology	"malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000040	absent middle ear ossicles	"missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000041	absent endolymphatic duct	"missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000077	abnormal interparietal bone morphology	"malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000079	abnormal basioccipital bone morphology	"malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0000080	abnormal exoccipital bone morphology	"malformed lateral part of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000273	overriding aorta	"congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000276	right ventricle hypertrophy	"increased size of the right ventricle" [J:33629]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pitx2^tm1Kki/Pitx2^tm1Kki Genetic Background: involves: 129P2/OlaHsd * C57BL
MP:0000680	absent parathyroid glands	"missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000705	athymia	"absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000743	muscle spasms	"muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hgf^tm1Kita/Hgf^tm1Kita Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000753	paralysis	"loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
MP:0000841	abnormal hindbrain morphology	"malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000842	absent superior olivary complex	"missing nucleus of neurons on the dorsal part of the lateral surface of the pons; it normally receives projection fibers from the cochlear nuclei and is prominently involved in spatial localization of sound " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000843	absent facial nuclei	"missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000910	small facial motor nucleus	"reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science:ISBN 0-8385-8034-3, J:56847]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000933	abnormal rhombomere morphology	"malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001056	abnormal cranial nerve morphology	"any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0001071	abnormal facial nerve morphology	"malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001073	abnormal glossopharyngeal nerve morphology	"malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0001074	abnormal vagus nerve morphology	"malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0001081	abnormal cranial ganglia morphology	"any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0001082	abnormal geniculate ganglion morphology	"malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001083	small geniculate ganglion	"reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001092	abnormal trigeminal ganglion morphology	"malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001098	small superior glossopharyngeal ganglion	"reduced size of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001101	abnormal superior vagus ganglion morphology	"malformation of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001102	small superior vagus ganglion	"reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Hoxa1^tm2Mrc/Hoxa1⁺,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Pitx2^tm1Kki/Pitx2^tm1Kki Genetic Background: involves: 129P2/OlaHsd * C57BL Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001961	abnormal reflex	"anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺,Hoxb1^tm5Mrc/Hoxb1^tm5Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001993	abnormal blinking		Show Allelic Composition: Fgfr1^tm1Upir/Fgfr1^tm1Upir,Foxg1^tm1(cre)Skm/Foxg1⁺ Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002163	abnormal gland morphology	"abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm1Mrc/Hoxa1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm2Mrc/Hoxa1⁺,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^{tm8(Hoxa1)Mrc}/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^{tm7.1(cre)Mrc}/Hoxa1^{tm7.1(cre)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002177	abnormal outer ear morphology	"malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002316	anoxia	"absence or almost complete absence of oxygen from inspired gases, blood, or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0002621	delayed neural tube closure	"delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002950	abnormal neural crest cell migration	"defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003146	absent cochlear ganglion	"absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [J:36834, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003147	absent cochlea	"absence or agenesis of the cochlea" [J:23837, J:36834, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003163	absent posterior semicircular canal		Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003165	absent superior semicircular canal		Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003494	parathyroid hypoplasia		Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003987	small vestibular ganglion	"reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004113	abnormal aortic arch morphology	"structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004160	retroesophageal right subclavian artery	"the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004204	absent stapes	"absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004249	abnormal crista ampullaris morphology	"anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004310	small otic vesicle	"reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004315	absent saccule	"absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004330	abnormal saccular macula morphology	"any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004333	abnormal utricular macula morphology	"any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004369	absent utricle	"absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004561	absent facial nerve	"absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004568	fusion of glossopharyngeal and vagus nerve	"union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0004715	absent vestibulocochlear nerve	"absence of the composite sensory nerve innervating the receptor cells of the membranous labyrinth " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004717	absent cochlear nerve	"absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the cochlear root" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004719	absent vestibular nerve	"absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the vestibular root " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004923	absent common crus	"absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0005579	absent outer ear	"missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]	Show Allelic Composition: Hoxa1^tm2Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006013	absent endolymphatic sac	"absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:1776:]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0006030	abnormal otic vesicle formation	"anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Hoxa1^tm8.2Mrc/Hoxa1^tm8.2Mrc Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
MP:0006031	abnormal branchial pouch morphology	"malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006344	small second branchial arch	"reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006345	absent second branchial arch	"missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008372	small malleus	"reduced size of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6 Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Hoxa1^tm2Mrc/Hoxa1⁺,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Hoxa1^tm2Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm2Mrc/Hoxa1⁺,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm8.2Mrc/Hoxa1^tm8.2Mrc Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Ipc/Hoxa1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm1Mrc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0012261	increased hindbrain apoptosis	"increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012730	abnormal internal carotid artery morphology	"any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012731	abnormal external carotid artery morphology	"any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012746	abnormal neural crest cell delamination	"any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [MGI:anna]	Show Allelic Composition: Cd28^tm1Mak/Cd28^tm1Mak Genetic Background: involves: 129S2/SvPas
MP:0012757	abnormal cranial neural crest cell migration	"any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0012794	increased rhombomere 3 size	"increased size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0012799	absent rhombomere 4	"absence of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012803	absent rhombomere 5	"absence of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012817	rhombomere fusion	"the union of one or more rhombomeres into a single structure" [MGI:csmith]	Show Allelic Composition: Hoxa1^tm1Rez/Hoxa1^tm1Rez Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6
MP:0013224	absent second pharyngeal pouch	"absence of the second branchial pouch, normally located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils" [PMID:20144910]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0013225	abnormal third pharyngeal pouch morphology	"any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030040	absent facial muscle	"absence of any of the striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression; facial muscles are derived from the second branchial/pharyngeal arch" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030106	small incus	"reduced size of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [https://radiopaedia.org/articles/incus]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030123	small middle ear ossicles	"reduced size of the three bones of the middle ear" [MGI:anna]	Show Allelic Composition: Hoxa1^tm1Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Hoxa1^tm2Mrc/Hoxa1^tm2Mrc,Hoxa2^tm1Mrc/Hoxa2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030141	facial paralysis	"complete loss of power of voluntary movement in muscles of the face through injury or disease of it or its nerve supply; facial muscles are innervated by the facial nerve (i.e., the seventh cranial nerve)" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc},Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0030146	abnormal digastric posterior belly morphology	"any structural anomaly of the longer, posterior belly of the digastric muscle arising from the mastoid notch which is on the inferior surface of the skull, medial to the mastoid process of the temporal bone; the posterior belly is supplied by the digastric branch of facial nerve" []	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030149	abnormal stylohyoid muscle morphology	"any structural anomaly of the slender suprahyoid muscle lying anterior and superior of the posterior belly of the digastric muscle; it arises from the styloid process of the temporal bone and inserts into the body of the hyoid bone; it is perforated, near its insertion, by the intermediate tendon of the digastric muscle; the stylohyoid elevates and retracts the hyoid bone, elongating the floor of the mouth during swallowing" []	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030174	absent orbicularis oculi muscle	"absence of the ring-like (sphincter) facial muscle composed of skeletal muscle fibers and arranged in concentric bands around the upper and lower eyelids; its primary function is to close the eyelids" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030177	absent levator labii superioris muscle	"missing the facial muscle that is shaped like a broad, flat sheet, the origin of which extends from the side of the nose to the zygomatic bone; its main function is to elevate the upper lip" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030207	absent zygomaticus muscle	"absence of the zygomaticus major and/or minor facial muscles that originate from the body of the zygoma and pass downwards to insert into the corner of the mouth and lateral aspect of the upper lip, respectively" [MGI:anna]	Show Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^tm3.1Mrc,Hoxb1^tm3Mrc/Hoxb1^tm3Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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