ENSMUSG00000079277


Mus musculus

Features
Gene ID: ENSMUSG00000079277
  
Biological name :Hoxd3
  
Synonyms : homeobox D3 / Hoxd3 / P09027
  
Possible biological names infered from orthology : P31249
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 74711927
Gene end: 74748442
  
Corresponding Affymetrix probe sets: 10472984 (MoGene1.0st)   1421537_at (Mouse Genome 430 2.0 Array)   1437664_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044809
Ensembl peptide - ENSMUSP00000107613
Ensembl peptide - ENSMUSP00000107614
Ensembl peptide - ENSMUSP00000134616
Ensembl peptide - ENSMUSP00000134633
NCBI entrez gene - 15434     See in Manteia.
MGI - MGI:96207
RefSeq - NM_010468
RefSeq Peptide - NP_034598
swissprot - Q3UZR4
swissprot - G3UZS5
swissprot - G3UZU1
swissprot - P09027
Ensembl - ENSMUSG00000079277
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxd3aENSDARG00000059280Danio rerio
 HOXD3ENSGALG00000023420Gallus gallus
 HOXD3ENSG00000128652Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*ENSMUSG0000004876352
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*ENSMUSG0000007956052
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*ENSMUSG0000007558820
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*ENSMUSG0000001470419
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*ENSMUSG0000002964419
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*ENSMUSG0000001897318
Hoxa1 / homeobox A1 / P49639*ENSMUSG0000002984418
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*ENSMUSG0000004244817
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*ENSMUSG0000005312916
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*ENSMUSG0000003594614
Gm28308ENSMUSG000001012981


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR025281  Domain of unknown function DUF4074


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IGI
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0045666 positive regulation of neuron differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0051216 cartilage development IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016235 aggresome ISO
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Hoxa3tm2Nrm/Hoxa3tm3.1Nrm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C3H * C57BL/6 * CBA/J

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3+,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxa3tm1Kth/Hoxa3tm1Kth,Hoxd3tm3(Hoxa3)Mrc/Hoxd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001051 abnormal somatic motor system morphology 
Show

Allelic Composition: Hoxa3tm3Mrc/Hoxa3tm3Mrc,Hoxd3tm2Mrc/Hoxd3tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm1Kth/Hoxa3tm1Kth
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm2Nrm/Hoxa3tm3.1Nrm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C3H * C57BL/6 * CBA/J

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003007 ectopic thymus "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3+,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxa3tm1Kth/Hoxa3tm1Kth,Hoxd3tm3(Hoxa3)Mrc/Hoxd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003955 abnormal ultimobranchial body "a sac-like structure emanating from the caudal-most branchial pouch of the embryo; develops into the lateral portion of the thyroid that produced calcitonin in higher vertebrates" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004568 fusion of glossopharyngeal and vagus nerve "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm3(Hoxa3)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0004659 abnormal odontoid process "any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A02.835.232.834.151.383.668]
Show

Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm3(Hoxa3)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm3Mrc/Hoxa3tm3Mrc,Hoxd3tm2Mrc/Hoxd3tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0009879 abnormal arcus anterior morphology "any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm3(Hoxa3)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009899 hyoid bone hypoplasia "underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0010701 fusion of atlas and odontoid process "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm3(Hoxa3)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0010729 absent arcus anterior "absence of the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa3tm1Kth/Hoxa3tm1Kth,Hoxd3tm3(Hoxa3)Mrc/Hoxd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010730 absent odontoid process "absence of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011513 abnormal vertebral artery morphology "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
Show

Allelic Composition: Pitx2tm1Kki/Pitx2tm1Kki
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011576 absent cervical atlas "absence of the first (topmost, C1) cervical vertebra which supports the globe of the head" [MGI:anna]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxa3tm2Nrm/Hoxa3tm2Nrm,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013290 persistent ultimobranchial bodies "partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells" [ISBN:032322153X]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013574 ectopic parathyroid gland "a parathyroid gland located outside of its normal position; in the normal adult mouse, the parathyroids are usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; because of their common pharyngeal pouch origin, ectopic thyroid and parathyroid tissue can occasionally be found in the thymus" [MGI:Anna]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3+,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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