ENSMUSG00000048763


Mus musculus

Features
Gene ID: ENSMUSG00000048763
  
Biological name :Hoxb3
  
Synonyms : Homeobox protein Hox-B3 / Hoxb3 / P09026
  
Possible biological names infered from orthology : homeobox B3 / P14651
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96323326
Gene end: 96347930
  
Corresponding Affymetrix probe sets: 10380654 (MoGene1.0st)   1427605_at (Mouse Genome 430 2.0 Array)   1456229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053426
Ensembl peptide - ENSMUSP00000091476
Ensembl peptide - ENSMUSP00000134435
NCBI entrez gene - 15410     See in Manteia.
MGI - MGI:96184
RefSeq - XM_011248757
RefSeq - NM_001079869
RefSeq - NM_010458
RefSeq - XM_006532288
RefSeq - XM_006532289
RefSeq - XM_006532290
RefSeq - XM_006532291
RefSeq - XM_006532283
RefSeq - XM_006532284
RefSeq - XM_006532285
RefSeq - XM_006532286
RefSeq Peptide - NP_001073338
RefSeq Peptide - NP_034588
swissprot - P09026
swissprot - G3UZC2
Ensembl - ENSMUSG00000048763
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb3aENSDARG00000029263Danio rerio
 HOXB3ENSGALG00000043219Gallus gallus
 HOXB3ENSG00000120093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*ENSMUSG0000007956053
Hoxd3 / P09027 / homeobox D3 / P31249*ENSMUSG0000007927752
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*ENSMUSG0000007558824
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*ENSMUSG0000001470421
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*ENSMUSG0000001897319
Hoxa1 / homeobox A1 / P49639*ENSMUSG0000002984418
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*ENSMUSG0000004244818
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*ENSMUSG0000002964418
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*ENSMUSG0000005312916
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*ENSMUSG0000003594614
Gm28308ENSMUSG000001012981


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR025281  Domain of unknown function DUF4074


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0021546 rhombomere development IDA
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IGI
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0050767 regulation of neurogenesis IDA
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0060216 definitive hemopoiesis IGI
 biological_processGO:0060324 face development IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001051 abnormal somatic motor system morphology 
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Allelic Composition: Hoxd3tm2Mrc/Hoxd3tm3(Hoxa3)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb3tm1.1Karl/Hoxb3tm1.1Karl,Hoxb4tm2.1Karl/Hoxb4tm2.1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002256 abnormal laryngeal cartilage morphology "any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Aspatm1Mata/Aspatm1Mata
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002258 abnormal cricoid cartilage morphology "any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Aspatm1Mata/Aspatm1Mata
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003007 ectopic thymus "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3+,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003955 abnormal ultimobranchial body "a sac-like structure emanating from the caudal-most branchial pouch of the embryo; develops into the lateral portion of the thyroid that produced calcitonin in higher vertebrates" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004445 small exoccipital bone "reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004568 fusion of glossopharyngeal and vagus nerve "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0004914 absent ultimobranchial body "absence of the sac-like structure emanating from the caudal-most branchial pouch of the embryo which develops into the lateral portion of the thyroid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009899 hyoid bone hypoplasia "underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009913 abnormal hyoid bone greater horn morphology "any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0010701 fusion of atlas and odontoid process "the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0011576 absent cervical atlas "absence of the first (topmost, C1) cervical vertebra which supports the globe of the head" [MGI:anna]
Show

Allelic Composition: Hoxb3tm1Mrc/Hoxb3tm1Mrc,Hoxd3tm1Mrc/Hoxd3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0013162 abnormal thyroid gland isthmus morphology "any structural anomaly of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland and usually covers the second and the third tracheal rings; the thyroid isthmus is variable in presence and size, can change shape and size, and can encompass a cranially extending pyramid lobe (lobus pyramidalis or processus pyramidalis), remnant of the thyroglossal duct" [MGI:anna]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0013163 absent thyroid gland isthmus "absence of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland" [MGI:anna]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0013290 persistent ultimobranchial bodies "partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells" [ISBN:032322153X]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0013574 ectopic parathyroid gland "a parathyroid gland located outside of its normal position; in the normal adult mouse, the parathyroids are usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; because of their common pharyngeal pouch origin, ectopic thyroid and parathyroid tissue can occasionally be found in the thymus" [MGI:Anna]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3+,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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