ENSG00000120093


Homo sapiens

Features
Gene ID: ENSG00000120093
  
Biological name :HOXB3
  
Synonyms : homeobox B3 / HOXB3 / P14651
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48548870
Gene end: 48604912
  
Corresponding Affymetrix probe sets: 208414_s_at (Human Genome U133 Plus 2.0 Array)   228904_at (Human Genome U133 Plus 2.0 Array)   231767_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446783
Ensembl peptide - ENSP00000420595
Ensembl peptide - ENSP00000449977
Ensembl peptide - ENSP00000308252
Ensembl peptide - ENSP00000417207
Ensembl peptide - ENSP00000417400
Ensembl peptide - ENSP00000418035
Ensembl peptide - ENSP00000418729
Ensembl peptide - ENSP00000418892
Ensembl peptide - ENSP00000419676
NCBI entrez gene - 3213     See in Manteia.
OMIM - 142966
RefSeq - XM_017024560
RefSeq - XM_006721854
RefSeq - XM_011524710
RefSeq - XM_011524719
RefSeq - XM_011524720
RefSeq - XM_011524721
RefSeq - XM_011524726
RefSeq - XM_017024558
RefSeq - NM_002146
RefSeq - XM_005257277
RefSeq - XM_005257280
RefSeq - XM_005257282
RefSeq Peptide - NP_001317251
RefSeq Peptide - NP_001317252
RefSeq Peptide - NP_002137
swissprot - F8VXG0
swissprot - P14651
swissprot - F8W1L2
swissprot - C9J2I3
Ensembl - ENSG00000120093
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb3aENSDARG00000029263Danio rerio
 HOXB3ENSGALG00000043219Gallus gallus
 Hoxb3ENSMUSG00000048763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXA3 / O43365 / homeobox A3ENSG0000010599753
HOXD3 / P31249 / homeobox D3ENSG0000012865250
HOXB2 / P14652 / homeobox B2ENSG0000017391725
HOXA2 / O43364 / homeobox A2ENSG0000010599622
PDX1 / P52945 / pancreatic and duodenal homeobox 1ENSG0000013951519
HOXA1 / P49639 / homeobox A1ENSG0000010599118
HOXD1 / Q9GZZ0 / homeobox D1ENSG0000012864518
HOXB1 / P14653 / homeobox B1ENSG0000012009418
GSX1 / Q9H4S2 / GS homeobox 1ENSG0000016984016
GSX2 / Q9BZM3 / GS homeobox 2ENSG0000018061315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR025281  Domain of unknown function DUF4074


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0021546 rhombomere development IEA
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 biological_processGO:0060324 face development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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