ENSG00000105997


Homo sapiens

Features
Gene ID: ENSG00000105997
  
Biological name :HOXA3
  
Synonyms : homeobox A3 / HOXA3 / O43365
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p15.2
Gene start: 27106184
Gene end: 27152581
  
Corresponding Affymetrix probe sets: 208604_s_at (Human Genome U133 Plus 2.0 Array)   235521_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484411
Ensembl peptide - ENSP00000379640
Ensembl peptide - ENSP00000429426
Ensembl peptide - ENSP00000430566
Ensembl peptide - ENSP00000324884
NCBI entrez gene - 3200     See in Manteia.
OMIM - 142954
RefSeq - XM_011515343
RefSeq - NM_030661
RefSeq - NM_153631
RefSeq - XM_005249730
RefSeq - XM_005249731
RefSeq - XM_005249732
RefSeq - XM_006715715
RefSeq Peptide - NP_109377
RefSeq Peptide - NP_705895
swissprot - E5RIJ8
swissprot - F2Z3A4
swissprot - O43365
swissprot - A0A024RA33
Ensembl - ENSG00000105997
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxa3aENSDARG00000103862Danio rerio
 HOXA3ENSGALG00000027925Gallus gallus
 Hoxa3ENSMUSG00000079560Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXB3 / P14651 / homeobox B3ENSG0000012009352
HOXD3 / P31249 / homeobox D3ENSG0000012865249
HOXB2 / P14652 / homeobox B2ENSG0000017391723
HOXA2 / O43364 / homeobox A2ENSG0000010599621
PDX1 / P52945 / pancreatic and duodenal homeobox 1ENSG0000013951519
HOXB1 / P14653 / homeobox B1ENSG0000012009417
HOXA1 / P49639 / homeobox A1ENSG0000010599117
HOXD1 / Q9GZZ0 / homeobox D1ENSG0000012864516
GSX2 / Q9BZM3 / GS homeobox 2ENSG0000018061314
GSX1 / Q9H4S2 / GS homeobox 1ENSG0000016984014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR025281  Domain of unknown function DUF4074


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEP
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010159 specification of animal organ position IEA
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048645 animal organ formation IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060017 parathyroid gland development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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