ENSG00000173917


Homo sapiens

Features
Gene ID: ENSG00000173917
  
Biological name :HOXB2
  
Synonyms : homeobox B2 / HOXB2 / P14652
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48540894
Gene end: 48544989
  
Corresponding Affymetrix probe sets: 205453_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331741
NCBI entrez gene - 3212     See in Manteia.
OMIM - 142967
RefSeq - NM_002145
RefSeq Peptide - NP_002136
swissprot - P14652
Ensembl - ENSG00000173917
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXB2ENSGALG00000025774Gallus gallus
 Hoxb2ENSMUSG00000075588Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXA2 / O43364 / homeobox A2ENSG0000010599652
HOXB3 / P14651 / homeobox B3ENSG0000012009330
HOXA3 / O43365 / homeobox A3ENSG0000010599729
HOXD3 / P31249 / homeobox D3ENSG0000012865226
PDX1 / P52945 / pancreatic and duodenal homeobox 1ENSG0000013951524
HOXB1 / P14653 / homeobox B1ENSG0000012009421
HOXA1 / P49639 / homeobox A1ENSG0000010599120
HOXD1 / Q9GZZ0 / homeobox D1ENSG0000012864520
GSX2 / Q9BZM3 / GS homeobox 2ENSG0000018061319
GSX1 / Q9H4S2 / GS homeobox 1ENSG0000016984019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002011 morphogenesis of an epithelial sheet IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0021569 rhombomere 3 development IEA
 biological_processGO:0021570 rhombomere 4 development IEA
 biological_processGO:0021612 facial nerve structural organization IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0048857 neural nucleus development IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr