ENSG00000128652


Homo sapiens

Features
Gene ID: ENSG00000128652
  
Biological name :HOXD3
  
Synonyms : homeobox D3 / HOXD3 / P31249
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 176136612
Gene end: 176173102
  
Corresponding Affymetrix probe sets: 206601_s_at (Human Genome U133 Plus 2.0 Array)   206602_s_at (Human Genome U133 Plus 2.0 Array)   217076_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392615
Ensembl peptide - ENSP00000249440
Ensembl peptide - ENSP00000386498
NCBI entrez gene - 3232     See in Manteia.
OMIM - 142980
RefSeq - XM_011511066
RefSeq - NM_006898
RefSeq - XM_005246513
RefSeq - XM_006712477
RefSeq - XM_011511065
RefSeq - XM_005246509
RefSeq - XM_005246510
RefSeq - XM_005246511
RefSeq Peptide - NP_008829
swissprot - P31249
swissprot - C9J1M3
Ensembl - ENSG00000128652
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxd3aENSDARG00000059280Danio rerio
 HOXD3ENSGALG00000023420Gallus gallus
 Hoxd3ENSMUSG00000079277Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXB3 / P14651 / homeobox B3ENSG0000012009350
HOXA3 / O43365 / homeobox A3ENSG0000010599750
HOXB2 / P14652 / homeobox B2ENSG0000017391722
HOXA2 / O43364 / homeobox A2ENSG0000010599620
PDX1 / P52945 / pancreatic and duodenal homeobox 1ENSG0000013951520
HOXA1 / P49639 / homeobox A1ENSG0000010599118
HOXB1 / P14653 / homeobox B1ENSG0000012009417
HOXD1 / Q9GZZ0 / homeobox D1ENSG0000012864517
GSX1 / Q9H4S2 / GS homeobox 1ENSG0000016984016
GSX2 / Q9BZM3 / GS homeobox 2ENSG0000018061314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR025281  Domain of unknown function DUF4074


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0021615 glossopharyngeal nerve morphogenesis IEA
 biological_processGO:0030878 thyroid gland development ISS
 biological_processGO:0045666 positive regulation of neuron differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis ISS
 biological_processGO:0051216 cartilage development ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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