ENSMUSG00000035946


Mus musculus

Features
Gene ID: ENSMUSG00000035946
  
Biological name :Gsx2
  
Synonyms : GS homeobox 2 / Gsx2 / P31316
  
Possible biological names infered from orthology : Q9BZM3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.3
Gene start: 75075601
Gene end: 75077893
  
Corresponding Affymetrix probe sets: 10522500 (MoGene1.0st)   1421601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123712
Ensembl peptide - ENSMUSP00000036625
NCBI entrez gene - 14843     See in Manteia.
MGI - MGI:95843
RefSeq - NM_133256
RefSeq Peptide - NP_573555
swissprot - E0CZ09
swissprot - P31316
Ensembl - ENSMUSG00000035946
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsx2ENSDARG00000043322Danio rerio
 ENSGALG00000035943Gallus gallus
 GSX2ENSG00000180613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*ENSMUSG0000005312943
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*ENSMUSG0000002964427
Hoxb2 / P0C1T1 / Homeobox protein Hox-B2 / P14652* / homeobox B2*ENSMUSG0000007558823
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*ENSMUSG0000001470421
Hoxd3 / P09027 / homeobox D3 / P31249*ENSMUSG0000007927720
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*ENSMUSG0000004244820
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*ENSMUSG0000007956020
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*ENSMUSG0000004876319
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*ENSMUSG0000001897319
Hoxa1 / homeobox A1 / P49639*ENSMUSG0000002984418
Gm28308ENSMUSG000001012981


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development IGI
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0021544 subpallium development IGI
 biological_processGO:0021575 hindbrain morphogenesis IMP
 biological_processGO:0021798 forebrain dorsal/ventral pattern formation IMP
 biological_processGO:0021889 olfactory bulb interneuron differentiation IMP
 biological_processGO:0021978 telencephalon regionalization IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0048663 neuron fate commitment IGI
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0060163 subpallium neuron fate commitment IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Nfkb2Lym1/Nfkb2Lym1
Genetic Background: involves: BALB/c

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gsx2tm2.2Kc/Gsx2tm2.2Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

Allelic Composition: Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129

 MP:0004103 abnormal ventral striatum morphology "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gsx1tm1Ssp/Gsx1tm1Ssp,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004186 abnormal area postrema "structural malformation or absence of the small, elevated area in the lateral wall of the inferior recess of the fourth ventricle, involved in the control of cardiorespiratory physiology" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Ascl1tm1And/Ascl1tm1And,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129 * 129S2/SvPas

Allelic Composition: Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Gsx2tm2.1Kc/Gsx2tm2.1Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gsx2tm2.2Kc/Gsx2tm2.2Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gsx1tm1Ssp/Gsx1tm1Ssp,Gsx2tm1Ssp/Gsx2tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Gsx2tm2.2Kc/Gsx2tm2.2Kc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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