ENSG00000143995


Homo sapiens

Features
Gene ID: ENSG00000143995
  
Biological name :MEIS1
  
Synonyms : MEIS1 / Meis homeobox 1 / O00470
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p14
Gene start: 66433452
Gene end: 66573869
  
Corresponding Affymetrix probe sets: 1559477_s_at (Human Genome U133 Plus 2.0 Array)   204069_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454209
Ensembl peptide - ENSP00000440571
Ensembl peptide - ENSP00000475161
Ensembl peptide - ENSP00000272369
Ensembl peptide - ENSP00000381518
Ensembl peptide - ENSP00000397418
NCBI entrez gene - 4211     See in Manteia.
OMIM - 601739
RefSeq - XM_017004146
RefSeq - XM_005264325
RefSeq - XM_017004141
RefSeq - XM_017004142
RefSeq - XM_017004143
RefSeq - XM_017004144
RefSeq - XM_017004145
RefSeq - NM_002398
RefSeq - XM_005264321
RefSeq - XM_005264322
RefSeq - XM_005264323
RefSeq - XM_005264324
RefSeq Peptide - NP_002389
swissprot - F5GYS8
swissprot - H0YNY8
swissprot - E9PDC4
swissprot - O00470
swissprot - U3KPR8
Ensembl - ENSG00000143995
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 meis1aENSDARG00000002937Danio rerio
 meis1bENSDARG00000012078Danio rerio
 MEIS1ENSGALG00000041626Gallus gallus
 Meis1ENSMUSG00000020160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MEIS2 / O14770 / Meis homeobox 2ENSG0000013413884
MEIS3 / Q99687 / Meis homeobox 3ENSG0000010541965
P55347 / PKNOX1 / PBX/knotted 1 homeobox 1ENSG0000016019936
PKNOX2 / Q96KN3 / PBX/knotted 1 homeobox 2ENSG0000016549536
TGIF1 / Q15583 / TGFB induced factor homeobox 1ENSG0000017742616
Q8IUE1 / TGIF2LX / TGFB induced factor homeobox 2 like, X-linkedENSG000001537799
Q8IUE0 / TGIF2LY / TGFB induced factor homeobox 2 like, Y-linkedENSG000001766799
TGIF2 / Q9GZN2 / TGFB induced factor homeobox 2ENSG000001187079


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002089 lens morphogenesis in camera-type eye IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation ISS
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120094 HOXB1 / P14653 / homeobox B1  / complex
 ENSG00000185630 PBX1 / P40424 / PBX homeobox 1  / complex






 

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contact: otassy@igbmc.fr