ENSG00000118707


Homo sapiens

Features
Gene ID: ENSG00000118707
  
Biological name :TGIF2
  
Synonyms : Q9GZN2 / TGFB induced factor homeobox 2 / TGIF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.23
Gene start: 36573488
Gene end: 36593950
  
Corresponding Affymetrix probe sets: 216262_s_at (Human Genome U133 Plus 2.0 Array)   218724_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481787
Ensembl peptide - ENSP00000475729
Ensembl peptide - ENSP00000476174
Ensembl peptide - ENSP00000362979
Ensembl peptide - ENSP00000362981
Ensembl peptide - ENSP00000452878
Ensembl peptide - ENSP00000453773
Ensembl peptide - ENSP00000475479
NCBI entrez gene - 60436     See in Manteia.
OMIM - 607294
RefSeq - NM_001199513
RefSeq - NM_001199514
RefSeq - NM_001199515
RefSeq - NM_021809
RefSeq Peptide - NP_001186442
RefSeq Peptide - NP_001186443
RefSeq Peptide - NP_001186444
RefSeq Peptide - NP_068581
swissprot - U3KQS0
swissprot - U3KQB5
swissprot - Q9GZN2
swissprot - H0YKN5
swissprot - U3KQ25
Ensembl - ENSG00000118707
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834857.1ENSDARG00000112895Danio rerio
 TGIF2ENSGALG00000024081Gallus gallus
 Tgif2ENSMUSG00000062175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TGIF1 / Q15583 / TGFB induced factor homeobox 1ENSG0000017742649
Q8IUE1 / TGIF2LX / TGFB induced factor homeobox 2 like, X-linkedENSG0000015377937
Q8IUE0 / TGIF2LY / TGFB induced factor homeobox 2 like, Y-linkedENSG0000017667925
PKNOX2 / Q96KN3 / PBX/knotted 1 homeobox 2ENSG0000016549520
P55347 / PKNOX1 / PBX/knotted 1 homeobox 1ENSG0000016019920
MEIS2 / O14770 / Meis homeobox 2ENSG0000013413819
MEIS3 / Q99687 / Meis homeobox 3ENSG0000010541917
MEIS1 / O00470 / Meis homeobox 1ENSG0000014399515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0010470 regulation of gastrulation IEA
 biological_processGO:0038092 nodal signaling pathway IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction






 

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