ENSDARG00000059337


Danio rerio

Features
Gene ID: ENSDARG00000059337
  
Biological name :tgif1
  
Synonyms : TGFB-induced factor homeobox 1 / tgif1
  
Possible biological names infered from orthology : P70284 / Q15583
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 9287409
Gene end: 9300160
  
Corresponding Affymetrix probe sets: Dr.139.1.S1_at (Zebrafish Array)   NM_199567_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000076869
Ensembl peptide - ENSDARP00000124837
Ensembl peptide - ENSDARP00000127055
NCBI entrez gene - 321756     See in Manteia.
RefSeq - NM_199567
RefSeq Peptide - NP_955861
swissprot - F8W267
swissprot - Q803F0
swissprot - R4GEZ0
ZFIN ID - ZDB-GENE-030131-475
Ensembl - ENSDARG00000059337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TGIF1ENSGALG00000014795Gallus gallus
 TGIF1ENSG00000177426Homo sapiens
 Tgif1ENSMUSG00000047407Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FO834857.1 / TGIF2* / Q9GZN2* / TGFB induced factor homeobox 2*ENSDARG0000011289541
meis3 / myeloid ecotropic viral integration site 3 / P97368* / Q99687* / Meis homeobox 3* / Homeobox protein Meis3 *ENSDARG0000000279520
meis1b / Meis homeobox 1 b / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000001207818
meis2a / Meis homeobox 2a / MEIS2* / P97367* / O14770* / Meis homeobox 2* / Homeobox protein Meis2 *ENSDARG0000009824018
pknox1.1 / pbx/knotted 1 homeobox 1.1 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000001876518
pknox1.2 / pbx/knotted 1 homeobox 1.2 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000003654218
meis2a / meis2b / Meis homeobox 2bENSDARG0000007784017
meis1a / Meis homeobox 1 a / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000000293717
pknox2 / pbx/knotted 1 homeobox 2 / Q8BG99* / Q96KN3* / Homeobox protein PKNOX2 *ENSDARG0000005534917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0021797 forebrain anterior/posterior pattern specification IGI
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0070654 sensory epithelium regeneration IMP
 biological_processGO:0072091 regulation of stem cell proliferation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000152 retina retina sensory epithelium regeneration increased occurrence , abnormal
retina has fewer parts of type retinal cone cell , abnormal
retina sensory epithelium regeneration decreased occurrence , abnormal
retina stem cell proliferation decreased occurrence , abnormal
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 ZFA:0009280 Muller cell Muller cell apical region molecular quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction / complex
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction / complex
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / reaction / complex






 

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