ENSGALG00000035701


Gallus gallus

Features
Gene ID: ENSGALG00000035701
  
Biological name :SMAD3
  
Synonyms : mothers against decapentaplegic homolog 3 / SMAD3
  
Possible biological names infered from orthology : P84022 / Q8BUN5 / SMAD family member 3
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 18812337
Gene end: 18872532
  
Corresponding Affymetrix probe sets: Gga.6180.1.S1_at (Chicken Array)   Gga.6180.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000055964
Ensembl peptide - ENSGALP00000058076
NCBI entrez gene - 395132     See in Manteia.
RefSeq - NM_204475
RefSeq - XM_015292068
RefSeq Peptide - NP_989806
swissprot - A0A1D5PYM1
swissprot - A0A1D5PSS6
Ensembl - ENSGALG00000035701
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad3aENSDARG00000036096Danio rerio
 smad3bENSDARG00000010207Danio rerio
 SMAD3ENSG00000166949Homo sapiens
 Smad3ENSMUSG00000032402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000001418487
SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000003600187
SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*ENSGALG0000000630962
SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*ENSGALG0000000997762
SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*ENSGALG0000001705061
SMAD4* / P97471* / Q13485* / SMAD family member 4* / Mothers against decapentaplegic homolog 4 *ENSGALG0000003941736
SMAD6 / mothers against decapentaplegic homolog 6 / O35182* / O43541* / SMAD family member 6*ENSGALG0000002589823
SMAD7B / Gallus gallus TGF-beta signal pathway antagonist Smad7 (SMAD7B), mRNA. / SMAD7* / O35253* / O15105* / SMAD family member 7*ENSGALG0000002954522
SMAD7* / O15105* / O35253* / SMAD family member 7*ENSGALG0000003716020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0002520 immune system development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007183 SMAD protein complex assembly IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0009880 embryonic pattern specification IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016202 regulation of striated muscle tissue development IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0019049 evasion or tolerance of host defenses by virus IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0038092 nodal signaling pathway IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048340 paraxial mesoderm morphogenesis IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048617 embryonic foregut morphogenesis IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0051098 regulation of binding IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0060039 pericardium development IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0061045 negative regulation of wound healing IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0071141 SMAD protein complex IEA
 cellular_componentGO:0071144 heteromeric SMAD protein complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031962 mineralocorticoid receptor binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:0070878 primary miRNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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