ENSGALG00000039417


Gallus gallus

Features
Gene ID: ENSGALG00000039417
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 4 / P97471 / Q13485 / SMAD4 / SMAD family member 4
  
Species: Gallus gallus
  
Chr. number: 25
Strand: -1
Band:
Gene start: 1838113
Gene end: 1844548
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000044859
Ensembl peptide - ENSGALP00000046467
swissprot - A0A1D5NWW6
swissprot - A0A1D5P1D3
Ensembl - ENSGALG00000039417
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-222b8.1ENSDARG00000045094Danio rerio
 si:dkey-222b8.1ENSDARG00000070428Danio rerio
 SMAD4ENSG00000141646Homo sapiens
 Smad4ENSMUSG00000024515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000003600134
SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000001418434
SMAD3 / mothers against decapentaplegic homolog 3 / P84022* / Q8BUN5* / SMAD family member 3*ENSGALG0000003570133
SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*ENSGALG0000000997732
SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*ENSGALG0000001705032
SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*ENSGALG0000000630932
SMAD6 / mothers against decapentaplegic homolog 6 / O35182* / O43541* / SMAD family member 6*ENSGALG0000002589822
SMAD7B / Gallus gallus TGF-beta signal pathway antagonist Smad7 (SMAD7B), mRNA. / SMAD7* / O35253* / O15105* / SMAD family member 7*ENSGALG0000002954520
SMAD7* / O15105* / O35253* / SMAD family member 7*ENSGALG0000003716019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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