ENSMUSG00000027796


Mus musculus

Features
Gene ID: ENSMUSG00000027796
  
Biological name :Smad9
  
Synonyms : Mothers against decapentaplegic homolog 9 / Q9JIW5 / Smad9
  
Possible biological names infered from orthology : O15198 / SMAD family member 9
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 54755582
Gene end: 54801257
  
Corresponding Affymetrix probe sets: 10492091 (MoGene1.0st)   1450265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029371
NCBI entrez gene - 55994     See in Manteia.
MGI - MGI:1859993
RefSeq - XM_006501729
RefSeq - NM_019483
RefSeq - XM_006501728
RefSeq Peptide - NP_062356
swissprot - Q9JIW5
swissprot - Q3UVC6
Ensembl - ENSMUSG00000027796
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alg5ENSDARG00000021938Danio rerio
 SMAD9ENSGALG00000017050Gallus gallus
 SMAD9ENSG00000120693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smad1 / P70340 / SMAD family member 1 / Q15797*ENSMUSG0000003168184
Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*ENSMUSG0000002154082
Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*ENSMUSG0000002456363
Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*ENSMUSG0000003240262
Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*ENSMUSG0000002451541
Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*ENSMUSG0000003686728
Smad7 / O35253 / SMAD family member 7 / O15105*ENSMUSG0000002588026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily
 IPR036578  SMAD MH1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0060348 bone development IGI
 biological_processGO:0060395 SMAD protein signal transduction IGI
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Otcspf/Y
Genetic Background: Not Specified

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Otcspf/Y
Genetic Background: Not Specified

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: X/Tspy-pstm2(Mlc3-Gdf8)Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Smad9tm1Rob/Smad9tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0003579 ovarian carcinoma 
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf/Y
Genetic Background: Not Specified

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad1tm1Rob/Smad1+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Smad5tm1Zuk/Smad5+,Smad9tm2.1Rob/Smad9tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rnf165Gt(P9-3F)Sor/Rnf165+,Smad9tm1Rob/Smad9tm1Rob,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / reaction / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSMUSG00000029050 Ski / SKI proto-oncogene / P12755*  / reaction / complex
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / complex / reaction
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / reaction / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / complex / reaction
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / reaction / complex
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr