ENSMUSG00000021796


Mus musculus

Features
Gene ID: ENSMUSG00000021796
  
Biological name :Bmpr1a
  
Synonyms : Bmpr1a / Bone morphotic protein receptor type-1A / P36895
  
Possible biological names infered from orthology : bone morphogenetic protein receptor type 1A / P36894
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 34410734
Gene end: 34503341
  
Corresponding Affymetrix probe sets: 10418927 (MoGene1.0st)   1425491_at (Mouse Genome 430 2.0 Array)   1425492_at (Mouse Genome 430 2.0 Array)   1425493_at (Mouse Genome 430 2.0 Array)   1425494_s_at (Mouse Genome 430 2.0 Array)   1451729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131984
Ensembl peptide - ENSMUSP00000035900
Ensembl peptide - ENSMUSP00000126852
Ensembl peptide - ENSMUSP00000129927
NCBI entrez gene - 12166     See in Manteia.
MGI - MGI:1338938
RefSeq - XM_017315806
RefSeq - NM_009758
RefSeq - XM_006518469
RefSeq - XM_006518470
RefSeq Peptide - NP_033888
swissprot - P36895
swissprot - Q53Z43
swissprot - Q60607
swissprot - E9Q2G5
swissprot - E9PW65
Ensembl - ENSMUSG00000021796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmpr1aaENSDARG00000019728Danio rerio
 bmpr1abENSDARG00000105045Danio rerio
 BMPR1AENSGALG00000002003Gallus gallus
 BMPR1AENSG00000107779Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*ENSMUSG0000005243068
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761348
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*ENSMUSG0000002683446
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053246
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683644
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053042
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215528
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*ENSMUSG0000003244026
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*ENSMUSG0000006139325
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*ENSMUSG0000006733625
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001880 Mullerian duct regression IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002062 chondrocyte differentiation IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003161 cardiac conduction system development IMP
 biological_processGO:0003183 mitral valve morphogenesis IMP
 biological_processGO:0003186 tricuspid valve morphogenesis IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IMP
 biological_processGO:0003272 endocardial cushion formation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0021998 neural plate mediolateral regionalization IMP
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IGI
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0048352 paraxial mesoderm structural organization IMP
 biological_processGO:0048368 lateral mesoderm development IMP
 biological_processGO:0048378 regulation of lateral mesodermal cell fate specification IGI
 biological_processGO:0048382 mesendoderm development IMP
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060896 neural plate pattern specification IMP
 biological_processGO:0060914 heart formation IMP
 biological_processGO:0061312 BMP signaling pathway involved in heart development IC
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1904414 positive regulation of cardiac ventricle development IMP
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905285 fibrous ring of heart morphogenesis IMP
 biological_processGO:2000772 regulation of cellular senescence IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098821 BMP receptor activity IMP


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000022 abnormal ear shape "malformation of the pattern of the external ear" [J:65038]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc
Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1M146L)2Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0000557 absent hindlimb "missing the entire posterior extremities" [MGI:tc, J:54637]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0000568 ectopic digits "positional abnormality of a digit" [J:50311]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000997 abnormal joint capsule morphology "anomalous structure of the sac that encloses the articulating ends of bones participating in a synovial joint " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1a+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0003189 fused joints 
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0003221 abnormal cardiomyocyte apoptosis "change in the timing or the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003813 abnormal dermal papilla "abnormalities in this specialized group of mesenchymal cells necessary for initiation of follicle development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003875 abnormal hair follicle regresssion "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0004421 enlarged parietal bone "increased size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0006045 mitral valve insufficiency "the mitral valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0008275 failure of endochondral bone ossification "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0010512 absent PR interval "absence of the ECG segment representing the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0010536 Ebstein s malformation of tricuspid valve "a congenital downward displacement of the septal and posterior leaflets of the tricuspid valve into the inlet portion of the right ventricle" [http://emedicine.medscape.com, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0010614 abnormal mitral valve cusp morphology "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0010622 abnormal tricuspid valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flaps of the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/?,Nstr2A/J/?,Trp53tm1Tyj/?
Genetic Background: involves: 129S2/SvPas * A/J * C57BL/6J

 MP:0010811 decreased type II pneumocyte number "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2Bhr,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Bmpr1atm2Bhr/Bmpr1atm2Bhr,Tg(KRT14-cre)43Smr/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Kdrtm1(cre)Sato/Kdr+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jag1Yo/Jag1Yo
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0011190 thick embryonic epiblast "increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0011192 decreased embryonic epiblast cell proliferation "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]
Show

Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: B6.129S7-Bmpr1atm1Bhr

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * Swiss

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm1Bhr
Genetic Background: 129S7/SvEvBrd-Bmpr1atm1Bhr

 MP:0012085 midface hypoplasia "underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1a+,Col2a1tm1.1Ksec/Col2a1tm1.1Ksec
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0012110 increased hair follicle number "greater number of the epidermal invaginations from which the hair shaft develops" [MGI:monikat]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Ctnnb1tm1Mmt/Ctnnb1+,Krt14tm1.1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

 MP:0013351 abnormal Rathke s pouch development "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0020084 short ears "reduced length of the ears" [GOC:NV]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr,Tg(Gdf5-cre-ALPP)1Kng/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / complex / reaction
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / reaction / complex
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / reaction / complex
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / reaction / complex
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / reaction / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / reaction / complex
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / reaction / complex
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / complex / reaction






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr